Original Article

Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Corresponding Author

Jonas Fellmann

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

Corresponding author: J. Fellmann, Alte Landstrasse 34, 8702 Zollikon, Switzerland. E-mail: [email protected]Search for more papers by this author

Jan U. Weisert MD,

Jan U. Weisert MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

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Alex Soltermann MD,

Alex Soltermann MD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

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Grégoire Morand MD,

Grégoire Morand MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

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Laura Morra PhD,

Laura Morra PhD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

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Holger Moch MD,

Holger Moch MD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

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Gerhard F. Huber MD, MSc,

Gerhard F. Huber MD, MSc

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

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Rudolf Probst MD,

Rudolf Probst MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

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Jonas Fellmann,

Corresponding Author

Jonas Fellmann

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

Corresponding author: J. Fellmann, Alte Landstrasse 34, 8702 Zollikon, Switzerland. E-mail: [email protected]Search for more papers by this author

Jan U. Weisert MD,

Jan U. Weisert MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Alex Soltermann MD,

Alex Soltermann MD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Grégoire Morand MD,

Grégoire Morand MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Laura Morra PhD,

Laura Morra PhD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Holger Moch MD,

Holger Moch MD

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Gerhard F. Huber MD, MSc,

Gerhard F. Huber MD, MSc

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

Search for more papers by this author

Rudolf Probst MD,

Rudolf Probst MD

Division of Otorhinolaryngology – Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland

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First published: 30 August 2013

https://doi.org/10.1002/hed.23492

Citations: 10

This work was presented at the XXIV International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, Trinity College, Dublin, Ireland, September 13, 2011; and the 99th Spring Meeting of the Swiss Society of Oto-Rhino-Laryngology – Head and Neck Surgery, Paul Klee Center, Berne, Switzerland, June 22, 2012.

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Abstract

Background

Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract (UADT) in patients with gastric colonization by Helicobacter pylori.

Methods

In a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction (PCR) was performed on matched formalin-fixed and paraffin-embedded tissues of the stomach and the oral cavity, pharynx, or larynx.

Results

Helicobacter pylori was found in 38% of the samples from the oral cavity, pharynx, and larynx. An association with malignancies in these regions or possible risk factors, such as age, smoking, or alcohol, was not found.

Conclusion

The upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1562–1566, 2014

REFERENCES

1 Lukes P, Astl J, Pavlík E, Potuzníková B, Sterzl I, Betka J. Helicobacter pylori in tonsillar and adenoid tissue and its possible role in oropharyngeal carcinogenesis. Folia Biol (Praha) 2008; 54: 33–39.
CAS PubMed Web of Science® Google Scholar
2 Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1: 1311–1315.
10.1016/S0140-6736(84)91816-6
CAS PubMed Web of Science® Google Scholar
3 Marshall BJ, Warren JR. The Nobel Prize in Physiology or Medicine 2005. Available at: http://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/. Accessed August 20, 2013.
Google Scholar
4 World Health Organization. Schistosomes, Liver Flukes and Helicobacter pylori: WHO; 1994 [updated 08/26/1997]. Available at: http://monographs.iarc.fr/ENG/Monographs/vol61/volume61.pdf. Accessed August 20, 2013.
Google Scholar
5 Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008; 134: 306–323.
10.1053/j.gastro.2007.11.009
CAS PubMed Web of Science® Google Scholar
6 Oshowo A, Tunio M, Gillam D, et al. Oral colonization is unlikely to play an important role in Helicobacter pylori infection. Br J Surg 1998; 85: 850–852.
10.1046/j.1365-2168.1998.00724.x
CAS PubMed Web of Science® Google Scholar
7 Dowsett SA, Kowolik MJ. Oral Helicobacter pylori: can we stomach it? Crit Rev Oral Biol Med 2003; 14: 226–233.
10.1177/154411130301400307
CAS PubMed Web of Science® Google Scholar
8 Elsheikh MN, Mahfouz ME. Prevalence of Helicobacter pylori DNA in recurrent aphthous ulcerations in mucosa-associated lymphoid tissues of the pharynx. Arch Otolaryngol Head Neck Surg 2005; 131: 804–808.
10.1001/archotol.131.9.804
PubMed Web of Science® Google Scholar
9 Shi Y, Gong H, Zhou L, et al. Association between Helicobacter pylori infection and laryngeal squamous cell carcinoma in a Chinese male population. ORL J Otorhinolaryngol Relat Spec 2011; 73: 295–300.
10.1159/000330955
PubMed Web of Science® Google Scholar
10 Rassekh CH, Rady PL, Arany I, et al. Combined Epstein–Barr virus and human papillomavirus infection in nasopharyngeal carcinoma. Laryngoscope 1998; 108: 362–367.
10.1097/00005537-199803000-00010
CAS PubMed Web of Science® Google Scholar
11 Isayeva T, Li Y, Maswahu D, Brandwein–Gensler M. Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol 2012; 6 Suppl 1: S104–S120.
10.1007/s12105-012-0368-1
PubMed Google Scholar
12 Kaptan ZK, Emir H, Uzunkulaoğlu H, et al. Determination of Helicobacter pylori in patients with chronic nonspecific pharyngitis. Laryngoscope 2009; 119: 1479–1483.
10.1002/lary.20253
PubMed Web of Science® Google Scholar
13 Wu CH, Hsiao TY, Ko JY, Hsu MM. Dysphagia after radiotherapy: endoscopic examination of swallowing in patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol 2000; 109: 320–325.
10.1177/000348940010900315
CAS PubMed Web of Science® Google Scholar
14 Keefe DM, Schubert MM, Elting LS, et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007; 109: 820–831.
10.1002/cncr.22484
CAS PubMed Web of Science® Google Scholar
15 Maeda S, Ogura K, Yoshida H, et al. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut 1998; 42: 338–343.
10.1136/gut.42.3.338
CAS PubMed Web of Science® Google Scholar
16 Soltermann A, Koetzer S, Eigenmann F, Komminoth P. Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. Mod Pathol 2007; 20: 878–883.
10.1038/modpathol.3800832
CAS PubMed Web of Science® Google Scholar
17 Ozyurt M, Gungor A, Ergunay K, Cekin E, Erkul E, Haznedaroglu T. Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg 2009; 141: 131–135.
10.1016/j.otohns.2009.04.005
PubMed Web of Science® Google Scholar
18 Rezaii J, Tavakoli H, Esfandiari K, et al. Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature. Head Neck 2008; 30: 1624–1627.
10.1002/hed.20918
CAS PubMed Web of Science® Google Scholar
19 Grandis JR, Perez–Perez GI, Yu VL, Johnson JT, Blaser MJ. Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer. Head Neck 1997; 19: 216–218.
10.1002/(SICI)1097-0347(199705)19:3<216::AID-HED9>3.0.CO;2-5
CAS PubMed Web of Science® Google Scholar
20 Nurgalieva ZZ, Graham DY, Dahlstrom KR, Wei Q, Sturgis EM. A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer. Head Neck 2005; 27: 22–27.
10.1002/hed.20108
PubMed Web of Science® Google Scholar
21 Soltermann A, Perren A, Schmid S, et al. Assessment of Helicobacter pylori clarithromycin resistance mutations in archival gastric biopsy samples. Swiss Med Wkly 2005; 135: 327–332.
CAS PubMed Web of Science® Google Scholar
22 Borromeo M, Lambert JR, Pinkard KJ. Evaluation of “CLO-test” to detect Campylobacter pyloridis in gastric mucosa. J Clin Pathol 1987; 40: 462–463.
10.1136/jcp.40.4.462
CAS PubMed Web of Science® Google Scholar
23 Mégraud F. A growing demand for Helicobacter pylori culture in the near future? Ital J Gastroenterol Hepatol 1997; 29: 574–576.
CAS PubMed Web of Science® Google Scholar
24 Laine L, Lewin D, Naritoku W, Estrada R, Cohen H. Prospective comparison of commercially available rapid urease tests for the diagnosis of Helicobacter pylori. Gastrointest Endosc 1996; 44: 523–526.
10.1016/S0016-5107(96)70002-0
CAS PubMed Web of Science® Google Scholar
25 Ricci C, Holton J, Vaira D. Diagnosis of Helicobacter pylori: invasive and non-invasive tests. Best Pract Res Clin Gastroenterol 2007; 21: 299–313.
10.1016/j.bpg.2006.11.002
PubMed Web of Science® Google Scholar
26 Teoman I, Ozmeriç N, Ozcan G, et al. Comparison of different methods to detect Helicobacter pylori in the dental plaque of dyspeptic patients. Clin Oral Investig 2007; 11: 201–205.
10.1007/s00784-007-0104-5
PubMed Web of Science® Google Scholar
27 Aslan S, Yilmaz I, Bal N, et al. Investigation of Helicobacter pylori in tonsillary tissue with Pronto Dry test and pathologic examination. Auris Nasus Larynx 2007; 34: 339–342.
10.1016/j.anl.2006.10.004
PubMed Web of Science® Google Scholar

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Volume36, Issue11

November 2014

Pages 1562-1566

Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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