Original Article

Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning

Corresponding Author

Allen M. Chen MD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

Corresponding author: A.M. Chen Department of Radiation Oncology David Geffen School of Medicine at UCLA 200 Medical Plaza, Suite B265 Los Angeles, CA 90095-6951. E-mail: [email protected]Search for more papers by this author

Megan E. Daly MD,

Megan E. Daly MD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Jing Cui PhD,

Jing Cui PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Mathew Mathai CMD,

Mathew Mathai CMD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Stanley Benedict PhD,

Stanley Benedict PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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James A. Purdy PhD,

James A. Purdy PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Allen M. Chen MD,

Corresponding Author

Allen M. Chen MD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

Megan E. Daly MD,

Megan E. Daly MD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Jing Cui PhD,

Jing Cui PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Mathew Mathai CMD,

Mathew Mathai CMD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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Stanley Benedict PhD,

Stanley Benedict PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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James A. Purdy PhD,

James A. Purdy PhD

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, California

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First published: 30 August 2013

https://doi.org/10.1002/hed.23477

Citations: 113

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Abstract

Background

The purpose of this study was to determine the effect of adaptive replanning on clinical outcome among patients treated by intensity-modulated radiotherapy (IMRT) for head and neck cancer.

Methods

Three hundred seventeen patients underwent IMRT with daily image-guidance for newly diagnosed squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60–74 Gy). Of these 317 patients, 51 (16%) underwent adaptive radiotherapy with modification of the original IMRT midway during treatment.

Results

The 2-year local-regional control was 88% for patients treated with adaptive replanning compared with 79% for patients treated without (p = .01). The median time to local-regional recurrence for the 4 patients treated by adaptive radiotherapy was 7 months (range, 3–15 months) with all failures occurring within the high-dose planning target volume (PTV).

Conclusion

Although the use of routine replanning is probably not necessary, our findings do suggest a significant benefit in appropriately selected patients. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1541–1546, 2014

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Citing Literature

Volume36, Issue11

November 2014

Pages 1541-1546

Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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