Volume 35, Issue 11 pp. E333-E337

Case Report

In situ mantle cell lymphoma in the nasopharynx

Triantafyllia Koletsa MD,

Triantafyllia Koletsa MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Konstantinos Markou MD,

Konstantinos Markou MD

Department of Otorhinolaryngology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

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Sevasti Ouzounidou MD,

Sevasti Ouzounidou MD

Department of Otorhinolaryngology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

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Fani Tsiompanou MD,

Fani Tsiompanou MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Georgios Karkavelas MD,

Georgios Karkavelas MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Ioannis Kostopoulos MD,

Corresponding Author

Ioannis Kostopoulos MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Pathology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. E-mail: [email protected]Search for more papers by this author

Triantafyllia Koletsa MD,

Triantafyllia Koletsa MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Konstantinos Markou MD,

Konstantinos Markou MD

Department of Otorhinolaryngology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

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Sevasti Ouzounidou MD,

Sevasti Ouzounidou MD

Department of Otorhinolaryngology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

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Fani Tsiompanou MD,

Fani Tsiompanou MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Georgios Karkavelas MD,

Georgios Karkavelas MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Ioannis Kostopoulos MD,

Corresponding Author

Ioannis Kostopoulos MD

Department of Pathology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Pathology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. E-mail: [email protected]Search for more papers by this author

First published: 22 December 2012

https://doi.org/10.1002/hed.23206

Citations: 8

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Abstract

Background

Mantle cell lymphoma (MCL) is a B-cell neoplasm with an aggressive clinical course. Recently, an indolent type of MCL has been described under the term in situ MCL.

Methods and Results

We report a case of a 70-year-old woman who presented with nasal obstruction. A mass, located in the nasopharynx, was found. Histologic examination revealed lymphoid hyperplasia characterized by CD5 and cyclin D1–positive mantle zone cells, findings consistent with in situ MCL. Three years later, a new biopsy was performed, which showed the same histologic and immunohistochemical (IHC) findings to those observed in the first biopsy. The diagnosis of in situ MCL was confirmed by fluorescence in situ hybridization (FISH) analysis for t(11;14). Since then, the patient has remained free of an overt lymphoma.

Conclusions

In situ MCL may be observed in the nasopharynx, and it would be appropriate to perform cyclin D1 immunostain in cases with marked follicular hyperplasia accompanied by clinical suspicion of lymphoma. © 2012 Wiley Periodicals, Inc. Head Neck, 35: E333–E337, 2013

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Volume35, Issue11

November 2013

Pages E333-E337

In situ mantle cell lymphoma in the nasopharynx

Abstract

Background

Methods and Results

Conclusions

REFERENCES

Citing Literature

References

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In situ mantle cell lymphoma in the nasopharynx

Abstract

Background

Methods and Results

Conclusions

REFERENCES

Citing Literature

References

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