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Synthesis of substituted thieno[2,3-bpyrroles

Hongtao Wei

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

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Jin Cai,

Jin Cai

Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu, P. R. China, 210009

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Min Sun,

Min Sun

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

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Min Ji,

Corresponding Author

Min Ji

[email protected]

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096Search for more papers by this author

Hongtao Wei,

Hongtao Wei

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

Search for more papers by this author

Jin Cai,

Jin Cai

Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu, P. R. China, 210009

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Min Sun,

Min Sun

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

Search for more papers by this author

Min Ji,

Corresponding Author

Min Ji

[email protected]

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096

Department of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 210096Search for more papers by this author

First published: 09 April 2007

https://doi.org/10.1002/hc.20290

Citations: 6

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Abstract

Thieno[2,3-b]pyrroles can be synthesized through three steps: Gewald synthesis, alkylation, and Thorpe–Ziegler cyclization. Diethyl 3,6-bis((ethoxycarbonyl)methyl)-4-amino-6H-thieno[2,3-b]pyrrole-2,5-dicarboxylate (13) has been obtained by one-pot method in DMF in good yield and high quality. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:236–238, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20290

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