International Journal of Geriatric Psychiatry

Volume 30, Issue 10 pp. 1068-1075

Research Article

Relationship between regional cerebral blood flow and neuropsychiatric symptoms in dementia with Lewy bodies

Taku Yoshida,

Taku Yoshida

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Takaaki Mori,

Takaaki Mori

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Kiyohiro Yamazaki,

Kiyohiro Yamazaki

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Naomi Sonobe,

Naomi Sonobe

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Hideaki Shimizu,

Hideaki Shimizu

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Teruhisa Matsumoto,

Teruhisa Matsumoto

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Keiichi Kikuchi,

Keiichi Kikuchi

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Masao Miyagawa,

Masao Miyagawa

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Teruhito Mochizuki,

Teruhito Mochizuki

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Shu-ichi Ueno,

Corresponding Author

Shu-ichi Ueno

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

Correspondence to: Shu-ichi Ueno, E-mail: [email protected]Search for more papers by this author

Taku Yoshida,

Taku Yoshida

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Takaaki Mori,

Takaaki Mori

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Kiyohiro Yamazaki,

Kiyohiro Yamazaki

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Naomi Sonobe,

Naomi Sonobe

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Hideaki Shimizu,

Hideaki Shimizu

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Teruhisa Matsumoto,

Teruhisa Matsumoto

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Keiichi Kikuchi,

Keiichi Kikuchi

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Masao Miyagawa,

Masao Miyagawa

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Teruhito Mochizuki,

Teruhito Mochizuki

Department of Radiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

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Shu-ichi Ueno,

Corresponding Author

Shu-ichi Ueno

Department of Neuropsychiatry, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan

Correspondence to: Shu-ichi Ueno, E-mail: [email protected]Search for more papers by this author

First published: 17 February 2015

https://doi.org/10.1002/gps.4263

Citations: 13

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Abstract

Objective

This aim of this study was to examine the mechanisms underlying the neuropsychiatric symptoms in dementia with Lewy bodies by investigating regional cerebral blood flow.

Methods

Participants were 27 patients who fulfilled the diagnostic criteria for probable dementia with Lewy bodies. All subjects underwent single-photon emission computed tomography scans using technetium-99 m hexamethylpropyleneamine oxime. Neuropsychiatric symptoms were evaluated by neuropsychiatric inventory. Multiple regression analyses using neuropsychiatric inventory and voxel-based analyses of covariance of the regional cerebral blood flow images between subjects with or without each neuropsychiatric symptom were performed. Additionally, similar voxel-based analyses of covariance between subjects with each neuropsychiatric symptom and normal subjects were performed.

Results

There were no significant correlations in any psychiatric symptoms in multiple regression analyses. All subjects had hallucination but none had euphoria. We analyzed eight neuropsychiatric symptom scores with the exception of hallucination and euphoria using voxel-based analyses of covariance. Significant differences of regional cerebral blood flow were shown in groups with agitation, disinhibition, and irritability. Subjects with agitation showed hypoperfusion in the parietal lobule, the precuneus, and the angular gyrus, and hyperperfusion in the fusiform gyrus, the lingual gyrus, and the thalamus. Subjects with disinhibition showed hypoperfusion in the left frontal gyrus. Subjects with irritability showed hyperperfusion in the right frontal gyrus. There were no significant differences in regional cerebral blood flow between subjects with any neuropsychiatric symptoms and normal subjects.

Conclusion

Supporting Information

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Citing Literature

Volume30, Issue10

October 2015

Pages 1068-1075

Relationship between regional cerebral blood flow and neuropsychiatric symptoms in dementia with Lewy bodies

Abstract

Objective

Methods

Results

Conclusion

Supporting Information

References

Citing Literature

References

Information

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Relationship between regional cerebral blood flow and neuropsychiatric symptoms in dementia with Lewy bodies

Abstract

Objective

Methods

Results

Conclusion

Supporting Information

References

Citing Literature

References

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