Associations of serotonergic genes with poststroke emotional incontinence
Corresponding Author
Jae-Min Kim
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Prof. J.-M. Kim, Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. E-mail: [email protected]Search for more papers by this authorRobert Stewart
King's College London, Institute of Psychiatry, London, UK
Search for more papers by this authorHee-Ju Kang
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorKyung-Yeol Bae
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorSung-Wan Kim
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorIl-Seon Shin
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorJoon-Tae Kim
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorMan-Seok Park
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorKi-Hyun Cho
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorJin-Sang Yoon
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorCorresponding Author
Jae-Min Kim
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Prof. J.-M. Kim, Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. E-mail: [email protected]Search for more papers by this authorRobert Stewart
King's College London, Institute of Psychiatry, London, UK
Search for more papers by this authorHee-Ju Kang
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorKyung-Yeol Bae
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorSung-Wan Kim
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorIl-Seon Shin
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorJoon-Tae Kim
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorMan-Seok Park
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorKi-Hyun Cho
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorJin-Sang Yoon
Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
Search for more papers by this authorAbstract
Objectives
Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.
Methods
In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5-HTT gene-linked promoter region (5-HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5-HTR2a 1438A/G, and 5-HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.
Results
PSEI was present in 37 (13.4%) patients. The 5-HTT gene-linked promoter region s/s genotype was independently associated with PSEI. No associations with STin2 VNTR and 5-HTR2a genes were found, and no significant gene–gene interactions were identified.
Conclusions
Stroke patients with 5-HTTLPR s allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.
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