Volume 10, Issue 6 pp. 665-669
Genetic Analysis of Multiple Quantitative Risk Factors for Complex Disease
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Linkage analysis in a large pedigree ascertained due to essential familial hypercholesterolemia

Dr. Joan E. Bailey-Wilson

Corresponding Author

Dr. Joan E. Bailey-Wilson

Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans, Louisiana

Department of Biometry and Genetics, Louisiana State University Medical Center, 1901 Perdido Street, New Orleans, LA 70112Search for more papers by this author
Alexander F. Wilson

Alexander F. Wilson

Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans, Louisiana

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Vaneeta Bamba

Vaneeta Bamba

Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans, Louisiana

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First published: 1993
Citations: 19

Abstract

Sib-pair linkage analysis was used to screen a large pedigree, ascertained through four members with hypercholesterolemia, for evidence of linkage between 12 quantitative traits and 15 genetic marker loci. Traits were analyzed on the untransformed, natural log and square root-transformed scales. After adjusting for multiple tests, there is a suggestion of linkage between height and the Kidd blood group on chromosome 18 and between VLDL cholesterol, and possibly triglyceride, and KM on chromosome 2. © 1993 Wiley-Liss, Inc.

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