Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets
Corresponding Author
Dr. M. A. Pericak-Vance
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Division of Neurology, P.O. Box 2900, Duke University Medical Center, Durham, NC 27710Search for more papers by this authorP. H. St. George-Hyslop
Tanzi Neuroscience Institute, University of Toronto, Toronto, Canada
Search for more papers by this authorP. C. Gaskell Jr.
Tanzi Neuroscience Institute, University of Toronto, Toronto, Canada
Search for more papers by this authorJ. Growdon
Department of Neurology, Massachusetts Genertal Hospital, Boston, Massachusetts
Search for more papers by this authorB. J. Crain
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorC. Hulette
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorJ. F. Gusella
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorL. Yamaoka
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorR. E. Tanzi
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts
Search for more papers by this authorA. D. Roses
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorJ. L. Haines
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts
Search for more papers by this authorCorresponding Author
Dr. M. A. Pericak-Vance
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Division of Neurology, P.O. Box 2900, Duke University Medical Center, Durham, NC 27710Search for more papers by this authorP. H. St. George-Hyslop
Tanzi Neuroscience Institute, University of Toronto, Toronto, Canada
Search for more papers by this authorP. C. Gaskell Jr.
Tanzi Neuroscience Institute, University of Toronto, Toronto, Canada
Search for more papers by this authorJ. Growdon
Department of Neurology, Massachusetts Genertal Hospital, Boston, Massachusetts
Search for more papers by this authorB. J. Crain
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorC. Hulette
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorJ. F. Gusella
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorL. Yamaoka
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorR. E. Tanzi
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts
Search for more papers by this authorA. D. Roses
Division of Neurology and J & K Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, North Carolina
Search for more papers by this authorJ. L. Haines
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts
Search for more papers by this authorAbstract
Familial Alzheimer disease is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for whom numerous markers on chromosomes 19 and 21 were typed, are described. © 1993 Wiley-Liss, Inc.
References
- Breitner JC, Folstein MF (1984): Familial Alzheimer dementia: a prevalent disorder with specific clinical features. Psychol Med 14: 63–80.
- Farrer LA, O'Sullivan DM, Cupples LA, Growdon JH, Myers RH (1989): Assessment of genetic risk for Alzheimer's disease among first degree relatives. Ann Neurol 25: 485–493.
- Huff FJ, Auerbach J, Chakravarti A, Boller F (1988): Risk of dementia in relatives of patients with Alzheimer's disease. Neurology 38: 786–790.
- McKhann C, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984): Clinical diagnosis of Alzheimer's disease: Report of the NINCD-ADRADA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939–944.
- Mohs RC, Breitner JCS, Silverman JM, Davis K (1987): Alzheimer's disease: morbid risk among first degree relatives approximates 50% by age 90. Arch Gen Psychiatry 44: 405–408.
- Nee LE, Polinksy RJ, Eldridge R, Weingartner H, Smallberg S, Ebert M (1983): A family with histologically confirmed Alzheimer's disease. Arch Neurol 40: 203–208.
- Pericak-Vance MA, Yamaoka LH, Haynes CS, Speer MC, Haines JL, Gaskell PC, Hung W-Y, Clark CM, Heyman AL, Trofatter JA, Eisenmenger JP, Gilbert JR, Lee JE, Alberts MJ, Dawson DV, Bartlett RJ, Earl NL, Siddique T, Vance JM, Conneally PM, Roses AD (1988): Genetic linkage studies in Alzheimer's disease families. Exp Neurol 102: 271–279.
- Pericak-Vance MA, Bebout JL, Gaskell PC, Yamaoka LH, Hung W-Y, Alberts MJ, Walker AP, Bartlett RJ, Haynes CA, Welsh KA, Earl NL, Heyman A, Clark CM, Roses AD (1991a): Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage. Am J Hum Genet 48: 1034–1050.
- Pericak-Vance MA, Haines JL, St. George-Hyslop PH, Bebout J, Haynes C, Tanzi R, Yamaoka L, Gusella, JF, Roses AD (1991b): Joint linkage analysis of chromosomes 19 and 21 loci in familial Alzheimer disease. Am J Hum Genet 49: 355A.
- Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Boehnke M, Bryant EM, Lampe TH, Nochlin D, Sumi SM, Deeb SS, Beyreuther K, Martin GM (1988): Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241: 1507–1510.
- Schellenberg GD, Pericak-Vance MA, Wijsman EM, Moore DK, Gaskell PC, Yamaoka LA, Bebout JL (1991): Linkage analysis of familial Alzheimer's disease using chromosome 21 markers. Am Hum Genet 48: 563–583.
- St. George-Hyslop PH, Myers RH, Haines JL, Farrer LA, Tanzi RE, Abe K, Polinsky RJ, Gusella JF (1989): Familial Alzheimer's disease: Progress and problems. Neurobiol Aging 10: 417–425.
- St. George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, Growdon J, Bruni A, Foncin J–F, Salmon D, Frommelt P, Amaducci L, Sorbi S, Piacentini S, Stewart GD, Hobbs WJ, Conneally PM, Gusella JF (1987): The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235: 885–890.
- St. George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven, Goate A, McLachlan Crapper DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growdon J, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montes M, Mortilla M, Nacmias N, Vaula G, Gusella JF, Hardy JA (1990): Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous entity. Nature 347: 194–197.
- Terry RD, Katzman R (1983): Senile dementia of the Alzheimer type. Ann Neurol 14: 497–506.
- Weeks D, Lange K (1988): The affected pedigree member method of linkage analysis. Am J Hum Genet 42: 315–326.
- Weitkamp LR, Nee L, Keats B, Polinksy RJ, Guttormsen S (1983): Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14. Am J Hum Genet 35: 443–453.
