Generation of a conditional loxP allele of the Pax3 transcription factor that enables selective deletion of the homeodomain
Srinagesh V. Koushik
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorHongmei Chen
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorJian Wang
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorCorresponding Author
Simon J. Conway
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CB2803, Augusta, GA 30912-2640Search for more papers by this authorSrinagesh V. Koushik
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorHongmei Chen
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorJian Wang
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Search for more papers by this authorCorresponding Author
Simon J. Conway
Institute of Molecular Medicine and Genetics & Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CB2803, Augusta, GA 30912-2640Search for more papers by this author
LITERATURE CITED
-
Auerbach R.
1954.
Analysis of the developmental effects of a lethal mutation in the house mouse.
J Exp Zoology
127:
305–329.
10.1002/jez.1401270206 Google Scholar
- Baldwin CT, Hoth CF, Macina RA, Milunsky A. 1995. Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature. Am J Med Genet 58: 115–122.
- Chalepakis G, Stoykova A, Wijnholds J, Tremblay P, Gruss P. 1993. Pax: gene regulators in the developing nervous system. J Neurobiol 24: 1367–1384.
- Chen J, Kubalak SW, Chien KR. 1998. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development 125: 1943–1949.
- Conway SJ, Godt RE, Hatcher C, Leatherbury L, Zolotouchnikov VV, Brotto MAP, Copp AJ, Kirby ML, Creazzo TL. 1997a. Neural crest is involved in development of abnormal myocardial function. J Mol Cell Cardiol 29: 2675–2685.
- Conway SJ, Henderson DJ, Kirby ML, Anderson RH, Copp AJ. 1997b. Development of a lethal Congenital heart defect in the Splotch (pax3) mutant mouse. Cardiovasc Res 36: 163–173.
- Conway SJ, Bundy J, Chen J, Dickman E, Rogers R, Will BM. 2000. Abnormal neural crest stem cell expansion is responsible for the conotruncal heart defects within the Splotch (Sp2H) mouse mutant. Cardiovascular Res 47: 314–328.
- Fortin AS, Underhill DA, Gros P. 1998. Helix 2 of the paired domain plays a key role in the regulation of DNA-binding by the Pax-3 homeodomain. Nucleic Acids Res 26: 4574–81.
- Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, Flavell RA. 2001. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 193: 741–754.
- Kochilas LK, Li J, Jin F, Buck CA, Epstein JA. 1999. p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium. Pediatr Res 45: 635–642.
- Li J, Liu KC, Jin F, Lu MM, Epstein JA. 1999. Transgenic rescue of congenital heart disease and spina bifida in Splotch mice. Development 126: 2495–2503.
- Machado AF, Martin LJ, Collins MD. 2001. pax3and the Splotch mutations: structure, function, and relationship to teratogenesis, including gene-chemical interactions. Curr Pharm Des 7: 751–785.
- Mansouri A. 1998. The role of pax3and Pax7 in development and cancer. Crit Rev Oncog 9: 141–149.
- Mansouri A, Pla P, Larue L, Gruss P. 2001. Pax3 acts cell autonomously in the neural tube and somites by controlling cell surface properties. Development 128: 1995–2005.
- Stuart ET, Kioussi C, Gruss P. 1994. Mammalian Pax genes. Annu Rev Genet 28: 219–36.
Citing Literature
