Response to letters to the editor: Caldwell et al. [2008]†‡
Jane C. Caldwell
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorJennifer Jinot
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorDanielle Devoney
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorJeffrey S. Gift
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorJane C. Caldwell
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorJennifer Jinot
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorDanielle Devoney
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorJeffrey S. Gift
U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, North Carolina
Search for more papers by this authorThe views expressed in this article are those of the authors, and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency.
This article is a US Government work and, as such, is in the public domain in the United States of America.

REFERENCES
- Abdo KM,Camargo CA,Davis D,Egilman D,Epstein SS,Froines J,Hattis D,Hooper K,Huff J,Infante PF,Jacobson MF,Teitelbaum DT,Tickner JA. 2007. Letter to the editor. Int J Occup Environ Health 13: 449–450.
- Belpoggi F,Soffritti M,Maltoni C. 1998. Pathological characterization of testicular tumours and lymphomas-leukemias, and their precursors observed in Sprague-Dawley rats exposed to methyl-tertiary-butyl-ether (MTBE). Eur J Oncol 3: 201–206.
- Caldwell JC,Jinot J,DeVoney D,Gift JS. 2008. Evaluation of evidence for infection as a mode of action of rat lymphoma. Environ Mol Mutagen 49: 155–164.
- Chandra M,Riley MG,Johnson DE. 1992. Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol 66: 496–502.
- Decreto Legislativo 116. 1992. Attuazinoe della direttiva n, 86/609/CEE in material di protezione degli animali utilizzati a fini sperimentali o ad altri fini scientifici [in Italian]. Supplemento ordinario alla Gazzetta Ufficiale 40: 5–25.
- Leakey JEA,Seng JE,Allaben WT. 2003. Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays. Toxicol Appl Pharmacol 193: 237–265.
- Magnuson G,Williams GM. 2008. Letter to the editor. Environ Health Perspect 116: A239–A240.
- Magnuson BA,Burdock GA,Doull J,Kroes RM,Marsh GM,Pariza MW,Spencer PS,Waddell WJ,Walker R,Williams GM. 2007. Aspartame: A safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol 37: 629–727.
- Maltoni C,Cotti G. 1988. Carcinogenicity of vinyl chloride in Sprague-Dawley rats after prenatal and postnatal exposure. Ann NY Acad Sci 534: 145–159.
- Maltoni C,Lefemine G,Cotti G. 1986. Experimental research on trichloroethylene carcinogenesis. In: C Maltoni, MA Mehlman, editors. Archive of Research on Industrial Carcinogenesis. Princeton, NJ: Princeton Scientific Publishing. Vol. 5, pp 45–153.
- Maltoni C,Ciliberti A,Cotti G,Perino G. 1988. Long-term carcinogenicity bioassays on acrylonitrile administered by inhalation and by ingestion to Sprague-Dawley rats. Ann NY Acad Sci 534: 179–202.
- Maltoni C,Ciliberti A,Cotti G,Conti B,Belpoggi F. 1989. Benzene, an experimental multipotential carcinogen: Results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ Health Perspect 82: 109–124.
- McMartin DN,Sahota PS,Gunson DE,Hsu HH,Spaet RH. 1992. Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicol Pathol 20: 212–225.
- Miller RA,Nadon NL. 2000. Principles of animal use for gerontological research. J Gerontol A Biol Sci Med Sci 55: B117–B123.
- Overcash RG,Lindsey JR,Cassell GH,Baker HJ. 1976. Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Am J Pathol 82: 171–190.
- Pratt I (Chair),Anton R,Barlow S,Boskou D,Castle L,Crebelli R,Dekant W,Engel K-H,Forsythe S,Grunow W,Heinonen N,Larsen J-C,Leclercq C,Mennes W,Milana MR,Rietjens I,Svensson K,Tobback P,Toldrá F. 2006. Opinion of the scientific panel on food additives, flavorings, processing aids and materials in contact with food (AFC) on a request from the commission related to a new long-term carcinogenicity study on aspartame. Question Number EFSA-Q-2005-122. European Food Saftey Authority. Available at http://www.efsa.europa.eu/EFSA/Scientific_ Opinion/afc_op_ej356_aspartame_en1,0.pdf.
- Schoeb TR. 2000. Respiratory diseases of rodents. Vet Clin North Am 3: 481–496.
- Schoeb TR,Juliana MM,Nicholds PW,Davis JK,Lindsey JR. 1993. Effects of viral and mycoplasmal infections, ammonia exposure, vitamin A deficiency, host age, and organism strain on adherence of Mycoplasma pulmnois in cultured rat trachea. Lab Anim Sci 43: 417–424.
- Soffritti M. 2008. Response to Letter to the editor. Environ Health Perspect 116: A240.
- Soffritti M,Belpoggi F,Cevolani D,Guarino M,Padovani M,Maltoni C. 2002. Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann NY Acad Sci 982: 46–69.
- Soffritti M,Belpoggi F,Esposti DD,Lambertini L. 2005. Aspartame induces lymphomas and leukemias in rats. Eur J Oncol 10: 107–116.
- Soffritti M,Belpoggi F,Degli Esposti D,Lambertini L,Tibaldi E,Rigano A. 2006. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 114: 379–385.
- Soffritti M,Belpoggi F,Tibaldi E,Esposti DD,Lauriola M. 2007. Life-span exposures to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect 115: 1293–1297.
- Soffritti M,Belpoggi F,Esposti DD,Falcioni L,Bua L. 2008. Consequences of exposure to carcinogens beginning during developmental life. Basic Clin Pharmacol Toxicol 102: 118–124.
- U.S. EPA (Environmental Protection Agency). 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Washington, DC: Risk Assessment Forum, U.S. Environmental Protection Agency. Available at http://oaspub.epa.gov/eims/eimscomm.getfile?p_download_id=439797.