Role of tumor necrosis factor-α in the regulation of activated synovial T cell growth: Downregulation of synovial T cells in rheumatoid arthritis patients
Ning-Sheng Lai
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taichung, Taichung, Taiwan, R.O.C
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C
Search for more papers by this authorJoung-Liang Lan
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taichung, Taichung, Taiwan, R.O.C
Search for more papers by this authorChia-Li Yu
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taipei, National Yang Ming University, Taipei, Taiwan, R.O.C
Search for more papers by this authorCorresponding Author
Rong-Hwa Lin
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C
Graduate Institute of Immunology, College of Medicine, National Taiwan University, No. 1., Sec. 1., Jen AiRd., Taipei, Taiwan, R.O.C. (Fax: +886-2-321-7921)Search for more papers by this authorNing-Sheng Lai
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taichung, Taichung, Taiwan, R.O.C
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C
Search for more papers by this authorJoung-Liang Lan
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taichung, Taichung, Taiwan, R.O.C
Search for more papers by this authorChia-Li Yu
Section of Allergy, Immunology and Rheumatology, Department of Medicine, Veterans General Hospital-Taipei, National Yang Ming University, Taipei, Taiwan, R.O.C
Search for more papers by this authorCorresponding Author
Rong-Hwa Lin
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C
Graduate Institute of Immunology, College of Medicine, National Taiwan University, No. 1., Sec. 1., Jen AiRd., Taipei, Taiwan, R.O.C. (Fax: +886-2-321-7921)Search for more papers by this authorAbstract
To characterize the role of tumor necrosis factor (TNF)-α in regulating synovial T cell growth, cell cycle progression associated with TNF-α in mitogen-activated synovial T cells of patients with rheumatoid arthritis (RA) were analyzed. After mitogen stimulation, the majority of synovial T cells in RA patients accumulated in S-phase. Anti-human TNF-α monoclonal antibody and soluble recombinant human TNF receptor (rhTNFR) can block S-phase accumulation. Furthermore, synovial fluid (SF) from RA patients was able to inhibit the proliferation of these S-phase-accumulated T cells. These data indicate that TNF-α could regulate activated synovial T cell growth by driving them into S-phase. Combined with the activities of other components of SF, TNF-α seems to play an important role in down-regulating activated synovial T cells in RA patients. In addition, the elevated level of soluble TNFR in the SF of disease-active RA patients is believed to be associated with the promotion of synovial T cell responses.
References
- 1 Teyton, L., Lotteau, V., Turmel, P., Auffray, C. and Charron, D. J., J. Immunol. 1987. 138: 1730.
- 2
Bottazzo, G. F.,
Pujol-Borrell, R.,
Hanafusa, T. and
Feldmann, M.,
Lancet
1983.
11: 1115.
10.1016/S0140-6736(83)90629-3 Google Scholar
- 3 Brennan, F. M., Field, M., Chu, C. Q., Feldmann, M. and Maini, R. N., Br. J. Rheumatol. 1991. 30 (suppl): 76.
- 4 Gionine, F. S., Nuki, G. and Duff, G. W., Ann. Rheum. Dis. 1988. 47: 768.
- 5 Saxne, T., Palladino, M. A., Heinegard, D., Talal, N. and Wollheim, F. A., Arthritis Rheum. 1988. 31: 1041.
- 6 Manicourt, D. H., Triki, R., Fukuda, K., Devogelaer, J. P., Deuxchaisnes, C. N. and Thonar, E. J. M. A., Arthritis Rheum. 1993. 36: 490.
- 7 Barrera, P., Boerbooms, A. M., Janssen, E. M., Sauerwein, R. W., Gallati, H., Mulder, J., Boo, T., Demacker, P. N. M., Putte, L. B. A. and Meer, J. W. M., Arthritis Rheum. 1993. 36: 1070.
- 8 Pascale, R. L., Leonardo, P., Fritz, H., Sylvette, B., Silvano, T., Harald, G., Pierre, A. G. and Dayer, J. M., Arthritis Rheum. 1993. 36: 485.
- 9 Haranaka, K., Satomi, M. and Sakurai, A., Int. J. Cancer 1984. 34: 263.
- 10 Le, J. and Vilcek, J., Lab. Invest. 1987. 56: 234.
- 11 Larrick, J. W. and Kunkel, S. L., Pharmaceut. Res. 1988. 5: 129.
- 12 Fiers, W., FEBS Lett. 1991. 285: 199.
- 13 Roux-Lombard, P., Punzi, L., Hasler, F., Bas, S., Todesco, S., Gallati, H. and Dayer, J. M., Arthritis Rheum. 1993. 36: 485.
- 14 Boehme, S. A. and Lenardo, M. J., Eur. J. Immunol. 1993. 23: 1552.
- 15 Hollander, A. P., Atkins, R. M., Eastwood, D. M., Dieppe, P. A. and Elson, C. J., Clin. Exp. Immunol. 1991. 83: 52.
- 16 Friedland, J. S., Shattock, R., Remick, D. G. and Griffin, G. F., Clin. Exp. Immunol. 1993. 91: 58.
- 17 Wilbrik, B., Holewijn, M., Bijlsma, J. W. J., van Roy, J. L. A. M., den Otter, W. and van Eden, W., Arthritis Rheum. 1993. 36: 514.
- 18 Cope, A. P., Londei, M., Chu, N. R., Cohen, S. B. A., Elliott, M. J., Brennan, F. M., Maini, R. N. and Feldmann, M., J. Clin. Invest. 1994. 94: 749.
- 19 Piquet, P. F., Grau, G. E., Vesin, C., Loetsher, H., Gentz, R. and Lesslauer, W., Immunology 1992. 77: 510.
- 20 Williams, R. O., Feldmann, M. and Maini, R. N., Proc. Natl. Acad. Sci. USA 1992. 89: 9784.
- 21 Arend, W. P. and Dayer, J.-M., Arthritis Rheum. 1995. 38: 151.
- 22 Walker, N. I., Harmon, B. V., Gobe, G. C. and Kerr, J. F. R., Archiev. Exp. Pathol. 1988. 13: 18.
- 23 Laster, S. M., Wood, J. G. and Gooding, L. R., J. Immunol. 1988. 142: 2629.
- 24 Mangan, D. F. and Wahl, S. M., J. Immunol. 1991. 147: 3408.
- 25 Robaye, B., Mosselmans, R., Fiers, W., Dumont, J. E. and Galand, P., Am. J. Pathol. 1991. 138: 447.
- 26 Wright, S. C., Kumar, P., Tam, A. W., Shen, N., Varma, M. and Larrick, J. W., J. Cell Biochem. 1992. 48: 344.
- 27 Beutler, B. and Cerami, A., Nature 1986. 320: 584.
- 28 Duke, R. C. and Cohen, J. J., Lymphokine Res. 1986. 5: 286.
- 29 Woods, K. M. and Chapes, S. K., J. Leukoc. Biol. 1993. 53: 37.
- 30 Robaye, B., Mosselmans, R., Fiers, W., Dumont, J. E. and Galand, P., Am. J. Pathol. 1991. 138: 447.
- 31 Muro, M., Naomoto, Y. and Orita, K., Jpn. J. Cancer Res. 1991. 82: 118.
- 32 Hackett, R. J., Davis, L. S. and Lipsky, P. E., J. Immunol. 1988. 140: 2639.
- 33 Scheurich, P., Thoma, B., Ucer, U. and Pfizenmaier, K., J. Immunol. 1987. 138: 1786.
- 34 Espevik, T., Brockhaus, M., Loetscher, H., Nonstad, U. and Shalaby, R., J. Exp. Med. 1990. 171: 415.
- 35 Tartaglia, L. A. and Goeddel, D. V., Immunol. Today 1992. 13: 151.
- 36 Loetscher, H., Pan, Y. C. E., Lahm, H. W., Gentz, R., Brockhaus, M., Tabuchi, H. and Lesslauer, W., Cell 1990. 61: 351.
- 37 Lewis, M., Tartaglia, L. A., Lee, A., Bennett, G. L., Rice, G. C., Wong, G. H. W., Chen, E. Y. and Goeddel, D. V., Proc. Natl. Acad. Sci. USA 1991. 88: 2830.
- 38 Brockhaus, M., Schoenfeld, H. J., Schlaeger, E. J., Hunziker, W., Lesslauer, W. and Loetscher, H., Proc. Natl. Acad. Sci. USA 1990. 87: 3127.
- 39 Ware, C. F., Crowe, P. D., Vanarsdale, T. L., Andrews, J. L., Grayson, M. H., Jerzy, R., Smith, C. A. and Goodwin, R. G., J. Immunol. 1991. 147: 4229.
- 40 Brennan, F. M., Gibbons, D. L., Mitchell, T., Cope, A. P., Maini, R. N. and Feldmann, M., Eur. J. Immunol. 1992. 22: 1907.
- 41 Naume, B., Shalaby, R., Lesslauer, W. and Espevik, T., J. Immunol. 1991. 146: 3045.
- 42 Tartaglia, L. A., Rothe, M., Hu, Y. F. and Goeddel, D. V., Cell 1993. 73: 213.
Citing Literature
