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The inflammation mediators interleukin 1 and hepatocyte-stimulating factor are differently regulated in human monocytes
Hinnak Northoff, Tilo Andus,
Thuy-Anh Tran-Thi,
Joachim Bauer, Karl Decker,
Bernd Kubanek, Peter C. Heinrich,
Tilo Andus
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorThuy-Anh Tran-Thi
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorKarl Decker
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorCorresponding Author
Peter C. Heinrich
Medizinische Universitätsklinik II, Freiburg
Biochemisches Institut, Hermann-Herder-Str. 7, D-7800 Freiburg, FRGSearch for more papers by this authorHinnak Northoff, Tilo Andus,
Thuy-Anh Tran-Thi,
Joachim Bauer, Karl Decker,
Bernd Kubanek, Peter C. Heinrich,
Tilo Andus
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorThuy-Anh Tran-Thi
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorKarl Decker
Biochemisches Institut, Universität Freiburg, Freiburg
Search for more papers by this authorCorresponding Author
Peter C. Heinrich
Medizinische Universitätsklinik II, Freiburg
Biochemisches Institut, Hermann-Herder-Str. 7, D-7800 Freiburg, FRGSearch for more papers by this authorAbstract
Human peripheral monocytes can be induced by bacterial lipopolysaccharide to produce the inflammatory mediators interleukin 1 (IL1) and hepatocyte-stimulating (HS) activity. IL 1 and HS activities were separated by gel permeation chromatography. It is also shown that the two monokines are differently regulated. Evidence for this stems from the finding that monocytes cultured for 24 h lose their ability to produce IL 1 in response to lipopolysaccharide, while synthesis of HS activity remains essentially unaffected.
References
- 1 Dinarello, C. A., New Engl. J. Med. 1984. 311: 1413.
- 2 Sipe, J. D., in A. Koj and A. H. Gordon (Eds.), The Acute Phase Response to Injury and Infection, Elsevier, Amsterdam 1985, p. 23.
- 3 Oppenheim, J. J., Kovacs, E. J., Matsushima, K. and Durum, S. K., Immunol. Today 1986. 7: 45.
- 4 Kushner, I., Ann. N.Y. Acad. Sci. 1982. 389: 39.
- 5 Schreiber, G. and Howlett, G., in H. Glaumann, T. Peters and C. Redman (Eds.), Plasma Protein Secretion by the Liver, Academic Press, London 1983, p. 423.
- 6 Koj, A., in A. Koj and A. H. Gordon (Eds.), The Acute Phase Response to Injury and Infection, Elsevier, Amsterdam 1985, p. 139.
- 7 Lomedico, P. T., Gubler, U., Hellmann, Ch. P., Dukovich, M., Giri, J. G., Pan, Y.-C. E., Collier, K., Semionow, R., Chua, A. O. and Mizel, S. B., Nature 1984. 312: 458.
- 8 Auron, P. E., Webb, A. C., Rosenwasser, L. J., Mucci, S. F., Rich, A., Wolf, S. M. and Dinarello, C. A., Proc. Natl. Acad. Sci. USA 1984. 81: 7907.
- 9 March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V., Gillis, S., Henney, C. S., Kronheim, S. R., Grabstein, K., Conlon, P. J., Hopp, T. P. and Cosman, D., Nature 1985. 315: 641.
- 10 Furutani, Y., Notake, M., Yamayoshi, M., Yamagishi, J., Nomura, H., Ohue, M., Furuta, R., Fukui, T., Yamada, M. and Nakamura, S., Nucleic Acids Res. 1985. 13: 5869.
- 11 Bauer, J., Weber, W., Tran-Thi, T.-A., Northoff, G.-H., Decker, K., Gerok, W. and Heinrich, P. C., FEBS Lett. 1985. 190: 271.
- 12 Ramadori, G., Sipe, J. D., Dinarello, C. A., Mizel, S. B. and Colten, H. R., J. Exp. Med. 1985. 162: 930.
- 13 Perlmutter, D. H., Goldberger, G., Dinarello, C. A., Mizel, S. B. and Colten, H. R., Science 1986. 232: 850.
- 14 Karin, M., Imbra, R. J., Heguy, A. and Wong, G., Mol. Cell. Biol. 1985. 5: 2866.
- 15 Fuller, G. M., Otto, J. M., Woloski, B. M., McGary, C. T. and Adams, M. A., J. Cell Biol. 1985. 101: 1481.
- 16 Fuller, G. M. and Ritchie, D. G., Ann. N.Y. Acad. Sci. USA 1982. 408: 491.
- 17 Baumann, H., Jahreis, G. P., Sauder, D. N. and Koj, A., J. Biol Chem. 1984. 259: 7331.
- 18 Koj, A., Gauldie, J., Regoeczi, E., Sauder, D. N. and Sweeney, G. D., Biochem. J. 1984. 224: 505.
- 19 Woloski, B. M. R. N. J. and Fuller, G. M., Proc. Natl. Acad. Sci. USA 1985. 82: 1443.
- 20 Bauer, J., Birmelin, M., Northoff, G.-H., Northemann, W., Tran-Thi, T.-A., Ueberberg, H., Decker, K. and Heinrich, P. C., FEBS Lett. 1984. 177: 89.
- 21 Baumann, H., Hill, R. E., Sauder, D. N. and Jahreis, G. P., J. Cell Biol. 1986. 102: 370.
- 22 Trechsel, U., Evequoz, V. and Fleisch, H., Biochem. J. 1985. 230: 339.
- 23 Kunkel, S. L., Chensue, S. W. and Phan, S. H., J. Immunol. 1986. 136: 186.
- 24 Brandwein, S. R., J. Biol. Chem. 1986. 261: 8624.
- 25 Katakami, Y., Nakao, Y., Matsui, T., Koizumi, T., Kaibuchi, K., Takai, Y. and Fujita, T., Biochem. Biophys. Res. Commun. 1986. 135: 355.
- 26 Nawroth, P. P., Bank, I., Handley, D., Cassimeris, J., Chess, L. and Stern, D., J. Exp. Med. 1986. 163: 1363.
- 27 Tran-Thi, T.-A., Phillips, J., Falk, K. and Decker, K., Exp. Mol. Pathol. 1985. 42: 89.
- 28 Gebhardt, R. and Mecke, D., Exp. Cell Res. 1979. 124: 349.
- 29 Tanaka, K., Sato, M. and Tomita, Y., J. Biochem. 1978. 84: 937.
- 30 Barnes, D. and Sato, G., Anal. Biochem. 1980. 102: 255.
- 31 Michaelopoulos, G. H. and Pilot, H. C., Exp. Cell Res. 1975. 94: 70.
- 32 Isom, H. C., Selott, T., Georgoff, I., Woodworth, C. and Mummaw, J., J. Natl. Acad. Sci. USA 1985. 85: 3252.
- 33 Andus, T., Gross, V., Tran-Thi, T.-A., Schreiber, G., Nagashima, M. and Heinrich, P. C., Eur. J. Biochem. 1983. 133: 561.
- 34 King, J. and Laemmli, U., J. Mol. Biol. 1971. 62: 465.
- 35 Bonner, W. M. and Laskey, R. A., Eur. J. Biochem. 1974. 46: 83.
- 36 Boyum, A., Scand. J. Clin. Lab. Invest. 1968. 21: 77.
- 37
Northoff, H.,
Carter, C. and
Oppenheim, J. J.,
J. Immunol.
1980.
125: 125.
10.4049/jimmunol.125.4.1823 Google Scholar
- 38 Gordon, A. H., Biochem. J. 1976. 159: 643.
- 39 Gauthier, F. and Ohlsson, K., Hoppe-Seyler's Z. Physiol. Chem. 1978. 359: 987.
- 40 Ritchie, D. G., Levy, B. A., Adams, M. A. and Fuller, G. M., Proc. Natl. Acad. Sci. USA 1982. 79: 1530.
- 41 Ritchie, D. G. and Fuller, G. M., Ann. N.Y. Acad. Sci. 1983. 408: 490.
- 42 Duff, G. W. and Atkins, E., J. Immunol. Methods 1982. 52: 333.
- 43 Dinarello, C. A., Rosenwasser, L. J. and Wolf, S. M., J. Immunol. 1981. 127: 2517.
- 44 Amento, E. P., Kurnick, J. T. and Krane, S. M., Immunolobiology 1982. 163: 276.
- 45 Fujiwara, H. and Ellner, J. J., J. Immunol. 1986. 136: 181.
- 46 Stadecker, M. J., Calderon, J., Karnovsky, M. L. and Unanue, E. R., J. Immunol. 1977. 119: 1738.
- 47 Gordon, M., Bray, M. A. and Morley, J., Nature 1976. 262: 401.
- 48 Metzger, Z., Hoffeld, J. T. and Oppenheim, J. J., J. Immunol. 1980. 124: 983.
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