Diabetes/Metabolism Research and Reviews

Research Article

Vibration perception threshold for sight-threatening retinopathy screening in type 2 diabetic outpatients

Jing Shen

Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

These authors contributed equally to this work.

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Yanyun Hu,

Yanyun Hu

These authors contributed equally to this work.

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Fang Liu,

Corresponding Author

Fang Liu

Correspondence to: Fang Liu and Weiping Jia, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.

E-mail: [email protected]; [email protected]

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Hui Zeng,

Hui Zeng

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Lianxi Li,

Lianxi Li

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Jun Zhao,

Jun Zhao

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Jungong Zhao,

Jungong Zhao

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Taishan Zheng,

Taishan Zheng

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Huijuan Lu,

Huijuan Lu

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Fengdi Lu,

Fengdi Lu

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Yuqian Bao,

Yuqian Bao

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Weiping Jia,

Corresponding Author

Weiping Jia

E-mail: [email protected]; [email protected]

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Jing Shen,

Jing Shen

These authors contributed equally to this work.

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Yanyun Hu,

Yanyun Hu

These authors contributed equally to this work.

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Fang Liu,

Corresponding Author

Fang Liu

E-mail: [email protected]; [email protected]

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Hui Zeng,

Hui Zeng

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Lianxi Li,

Lianxi Li

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Jun Zhao,

Jun Zhao

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Jungong Zhao,

Jungong Zhao

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Taishan Zheng,

Taishan Zheng

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Huijuan Lu,

Huijuan Lu

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Fengdi Lu,

Fengdi Lu

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Yuqian Bao,

Yuqian Bao

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Weiping Jia,

Corresponding Author

Weiping Jia

E-mail: [email protected]; [email protected]

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First published: 08 May 2013

https://doi.org/10.1002/dmrr.2423

Citations: 7

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Abstract

Objective

We investigated the relationship between vibration perception threshold and diabetic retinopathy and verified the screening value of vibration perception threshold for severe diabetic retinopathy.

Methods

A total of 955 patients with type 2 diabetes were recruited and divided into three groups according to their fundus oculi photography results: no diabetic retinopathy (n = 654, 68.48%), non-sight-threatening diabetic retinopathy (n = 189, 19.79%) and sight-threatening diabetic retinopathy (n = 112, 11.73%). Their clinical and biochemical characteristics, vibration perception threshold and the diabetic retinopathy grades were detected and compared.

Results

There were significant differences in diabetes duration and blood glucose levels among three groups (all p < 0.05). The values of vibration perception threshold increased with the rising severity of retinopathy, and the vibration perception threshold level of sight-threatening diabetic retinopathy group was significantly higher than both non-sight-threatening diabetic retinopathy and no diabetic retinopathy groups (both p < 0.01). The prevalence of sight-threatening diabetic retinopathy in vibration perception threshold >25 V group was significantly higher than those in 16–24 V group (p < 0.01). The severity of diabetic retinopathy was positively associated with diabetes duration, blood glucose indexes and vibration perception threshold (all p < 0.01). Multiple stepwise regression analysis proved that glycosylated haemoglobin (β = 0.385, p = 0.000), diabetes duration (β = 0.275, p = 0.000) and vibration perception threshold (β = 0.180, p = 0.015) were independent risk factors for diabetic retinopathy. Receiver operating characteristic analysis further revealed that vibration perception threshold higher than 18 V was the optimal cut point for reflecting high risk of sight-threatening diabetic retinopathy (odds ratio = 4.20, 95% confidence interval = 2.67–6.59).

Conclusion

There was a close association between vibration perception threshold and the severity of diabetic retinopathy. vibration perception threshold was a potential screening method for diabetic retinopathy, and its optimal cut-off for prompting high risk of sight-threatening retinopathy was 18 V. Copyright © 2013 John Wiley & Sons, Ltd.

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Volume29, Issue7

October 2013

Pages 525-531

Vibration perception threshold for sight-threatening retinopathy screening in type 2 diabetic outpatients

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Vibration perception threshold for sight-threatening retinopathy screening in type 2 diabetic outpatients

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