Melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1: A case report with emphasis on intraoperative cytological findings
Kant M. Matsuda M.D., Ph.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorRaíssa Nóbrega M.D. (Student)
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorMartha Quezado M.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorDavid S. Schrump M.D.
Sugery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorCorresponding Author
Armando C. Filie M.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Laboratory of Pathology, National Cancer Insittute, 10 Center Drive, Building 10 Room 2A19, Bethesda, MD 20892Search for more papers by this authorKant M. Matsuda M.D., Ph.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorRaíssa Nóbrega M.D. (Student)
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorMartha Quezado M.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorDavid S. Schrump M.D.
Sugery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorCorresponding Author
Armando C. Filie M.D.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Laboratory of Pathology, National Cancer Insittute, 10 Center Drive, Building 10 Room 2A19, Bethesda, MD 20892Search for more papers by this authorAbstract
We present the cytological features along with histologic and imaging findings of a melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1 (MEN-1). Intraoperative touch preparations of the lung tumor showed single spindle cells and loosely cohesive aggregates of spindle cells with oval to elongated nuclei, “salt and pepper” chromatin pattern and inconspicuous nucleoli. The spindle cells occasionally contained cytoplasmic pigment, which revealed to be melanin by Fontana Masson stain on permanent processed material. Immunohistochemical stains for both synaptophysin and chromogranin were strongly positive in the spindle cells. The findings were consistent with melanocytic bronchopulmonary carcinoid tumor, which is relatively uncommon in MEN-1. Diagn. Cytopathol. 2010;38:669–674. © 2009 Wiley-Liss, Inc.
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