Association between anhedonia and suicidal events in patients with mood disorders: A 3-year prospective study
Corresponding Author
Déborah Ducasse
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Correspondence Déborah Ducasse, Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, 371 Avenue Gaston Giraud, 34295 Montpellier, France.
Email: [email protected]
Search for more papers by this authorJonathan Dubois
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Search for more papers by this authorIsabelle Jaussent
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Search for more papers by this authorJean-Michel Azorin
Fondation FondaMental, Créteil, France
AP HM, Psychiatric Pole, Marseille, France
Search for more papers by this authorBruno Etain
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorSébastien Gard
Fondation FondaMental, Créteil, France
Charles Perrens Hospital, Bordeaux, France
Search for more papers by this authorChantal Henry
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorThierry Bougerol
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorJean-Pierre Kahn
Fondation FondaMental, Créteil, France
Brabois Hospital, Academic Hospital of Nancy, Vandoeuvre Les Nancy, France
Search for more papers by this authorValérie Aubin
Fondation FondaMental, Créteil, France
Department of Psychiatry, Princesse-Grace Hospital, La Colle, Monaco
Search for more papers by this authorFrank Bellivier
Fondation FondaMental, Créteil, France
Hospital Saint-Louis–Lariboisière–Fernand Widal, AP-HP, Paris, France
Search for more papers by this authorRaoul Belzeaux
Fondation FondaMental, Créteil, France
AP HM, Psychiatric Pole, Marseille, France
Search for more papers by this authorCaroline Dubertret
Fondation FondaMental, Créteil, France
Department of Psychiatry, Louis Mourier Hospital, AP-HP, INSERM U894, School of Medicine, Paris Diderot University, Sorbonne Paris Cité, France
Department of Psychiatry and Clinical Psychology, Psychotherapy Center of Nancy and School of Medicine, Lorraine University, Lorraine, France
Search for more papers by this authorJulien Dubreucq
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorPierre-Michel Llorca
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorJosephine Loftus
Fondation FondaMental, Créteil, France
Department of Psychiatry, Princesse-Grace Hospital, La Colle, Monaco
Search for more papers by this authorChristine Passerieux
Fondation FondaMental, Créteil, France
Academic Hospital of Versailles, Le Chesnay, France
Search for more papers by this authorMircea Polosan
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorLudovic Samalin
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorMarion Leboyer
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorAntoine Yrondi
Fondation FondaMental, Créteil, France
Service de Psychiatrie et de Psychologie Médicale de l'adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Toulouse, Hôpital Purpan, Toulouse, France
Search for more papers by this authorDjamila Bennabi
Fondation FondaMental, Créteil, France
Service de Psychiatrie clinique, Centre Expert Dépression Résistante FondaMental, EA 481 Neurosciences, Université de Bourgogne Franche Comté, Besançon, France
Search for more papers by this authorEmmanuel Haffen
Fondation FondaMental, Créteil, France
Service de Psychiatrie clinique, Centre Expert Dépression Résistante FondaMental, Centre Investigation Clinique 1431-INSERM, EA 481 Neurosciences, Université de Bourgogne Franche Comté, Besançon, France
Search for more papers by this authorJulia Maruani
Fondation FondaMental, Créteil, France
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Hôpital Fernand-Widal, Paris, France
Search for more papers by this authorEtienne Allauze
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorVincent Camus
Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante FondaMental, Inserm U1253 Imaging and Brain, CHRU de Tours, Tours, France
Search for more papers by this authorThierry D'Amato
Service Universitaire de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Centre Hospitalier Le Vinatier, Bron cedex, France
Search for more papers by this authorJérôme Holtzmann
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorChristophe Lançon
Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La Conception, Marseille, France
Search for more papers by this authorFanny Moliere
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Search for more papers by this authorRémi Moirand
Service Universitaire de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Centre Hospitalier Le Vinatier, Bron cedex, France
Search for more papers by this authorRaphaëlle Marie Richieri
Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La Conception, Marseille, France
Search for more papers by this authorMathilde Horn
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France
Search for more papers by this authorLaurent Schmitt
Service de Psychiatrie et de Psychologie Médicale de l'adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Toulouse, Hôpital Purpan, Toulouse, France
Search for more papers by this authorFlorian Stephan
Service de Psychiatrie de l'adulte, Centre Expert Dépression Résistante FondaMental, CHU de Brest, Hôpital de Bohars, Bohars, France
Search for more papers by this authorJean-Baptiste Genty
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorGuillaume Vaiva
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France
Search for more papers by this authorMichel Walter
Service de Psychiatrie de l'adulte, Centre Expert Dépression Résistante FondaMental, CHU de Brest, Hôpital de Bohars, Bohars, France
Search for more papers by this authorWissam El-Hage
Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante FondaMental, Inserm U1253 Imaging and Brain, CHRU de Tours, Tours, France
Search for more papers by this authorEmilie Olié
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Search for more papers by this authorPhilippe Courtet
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Search for more papers by this authorCorresponding Author
Déborah Ducasse
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Correspondence Déborah Ducasse, Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, 371 Avenue Gaston Giraud, 34295 Montpellier, France.
Email: [email protected]
Search for more papers by this authorJonathan Dubois
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Search for more papers by this authorIsabelle Jaussent
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Search for more papers by this authorJean-Michel Azorin
Fondation FondaMental, Créteil, France
AP HM, Psychiatric Pole, Marseille, France
Search for more papers by this authorBruno Etain
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorSébastien Gard
Fondation FondaMental, Créteil, France
Charles Perrens Hospital, Bordeaux, France
Search for more papers by this authorChantal Henry
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorThierry Bougerol
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorJean-Pierre Kahn
Fondation FondaMental, Créteil, France
Brabois Hospital, Academic Hospital of Nancy, Vandoeuvre Les Nancy, France
Search for more papers by this authorValérie Aubin
Fondation FondaMental, Créteil, France
Department of Psychiatry, Princesse-Grace Hospital, La Colle, Monaco
Search for more papers by this authorFrank Bellivier
Fondation FondaMental, Créteil, France
Hospital Saint-Louis–Lariboisière–Fernand Widal, AP-HP, Paris, France
Search for more papers by this authorRaoul Belzeaux
Fondation FondaMental, Créteil, France
AP HM, Psychiatric Pole, Marseille, France
Search for more papers by this authorCaroline Dubertret
Fondation FondaMental, Créteil, France
Department of Psychiatry, Louis Mourier Hospital, AP-HP, INSERM U894, School of Medicine, Paris Diderot University, Sorbonne Paris Cité, France
Department of Psychiatry and Clinical Psychology, Psychotherapy Center of Nancy and School of Medicine, Lorraine University, Lorraine, France
Search for more papers by this authorJulien Dubreucq
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorPierre-Michel Llorca
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorJosephine Loftus
Fondation FondaMental, Créteil, France
Department of Psychiatry, Princesse-Grace Hospital, La Colle, Monaco
Search for more papers by this authorChristine Passerieux
Fondation FondaMental, Créteil, France
Academic Hospital of Versailles, Le Chesnay, France
Search for more papers by this authorMircea Polosan
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorLudovic Samalin
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorMarion Leboyer
Fondation FondaMental, Créteil, France
Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil, France
Search for more papers by this authorAntoine Yrondi
Fondation FondaMental, Créteil, France
Service de Psychiatrie et de Psychologie Médicale de l'adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Toulouse, Hôpital Purpan, Toulouse, France
Search for more papers by this authorDjamila Bennabi
Fondation FondaMental, Créteil, France
Service de Psychiatrie clinique, Centre Expert Dépression Résistante FondaMental, EA 481 Neurosciences, Université de Bourgogne Franche Comté, Besançon, France
Search for more papers by this authorEmmanuel Haffen
Fondation FondaMental, Créteil, France
Service de Psychiatrie clinique, Centre Expert Dépression Résistante FondaMental, Centre Investigation Clinique 1431-INSERM, EA 481 Neurosciences, Université de Bourgogne Franche Comté, Besançon, France
Search for more papers by this authorJulia Maruani
Fondation FondaMental, Créteil, France
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Hôpital Fernand-Widal, Paris, France
Search for more papers by this authorEtienne Allauze
Fondation FondaMental, Créteil, France
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorVincent Camus
Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante FondaMental, Inserm U1253 Imaging and Brain, CHRU de Tours, Tours, France
Search for more papers by this authorThierry D'Amato
Service Universitaire de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Centre Hospitalier Le Vinatier, Bron cedex, France
Search for more papers by this authorJérôme Holtzmann
Service de Psychiatrie de l'adulte, CS 10217, Centre Expert Dépression Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France
Search for more papers by this authorChristophe Lançon
Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La Conception, Marseille, France
Search for more papers by this authorFanny Moliere
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Search for more papers by this authorRémi Moirand
Service Universitaire de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, Centre Hospitalier Le Vinatier, Bron cedex, France
Search for more papers by this authorRaphaëlle Marie Richieri
Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La Conception, Marseille, France
Search for more papers by this authorMathilde Horn
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France
Search for more papers by this authorLaurent Schmitt
Service de Psychiatrie et de Psychologie Médicale de l'adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Toulouse, Hôpital Purpan, Toulouse, France
Search for more papers by this authorFlorian Stephan
Service de Psychiatrie de l'adulte, Centre Expert Dépression Résistante FondaMental, CHU de Brest, Hôpital de Bohars, Bohars, France
Search for more papers by this authorJean-Baptiste Genty
Service de Psychiatrie de l'adulte B, Centre Expert Dépression Résistante FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France
Search for more papers by this authorGuillaume Vaiva
Service de Psychiatrie adulte, Centre Expert Dépression Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France
Search for more papers by this authorMichel Walter
Service de Psychiatrie de l'adulte, Centre Expert Dépression Résistante FondaMental, CHU de Brest, Hôpital de Bohars, Bohars, France
Search for more papers by this authorWissam El-Hage
Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante FondaMental, Inserm U1253 Imaging and Brain, CHRU de Tours, Tours, France
Search for more papers by this authorEmilie Olié
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Search for more papers by this authorPhilippe Courtet
CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and Post Acute Care, CHRU, Montpellier, France
Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France
Fondation FondaMental, Créteil, France
Search for more papers by this authorAbstract
Background
As almost all mental disorders are associated with increased suicidal-related behavior, anhedonia might be a trans-diagnostic dimension to target for suicide prevention.
Methods
For this 3-year-long prospective study, 2,839 outpatients with mood disorders were recruited. They were divided in: (a) two groups according to the occurrence or not of suicidal ideation during the follow-up, and (b) two groups according to the occurrence or not of suicide attempts during the follow-up. Anhedonia was assessed using a composite score (the French version of the 14-item Snaith-Hamilton Pleasure Scale and item 13 of the Quick Inventory of Depressive Symptomatology scale) at inclusion and at 6, 12, 24, and 36 months after inclusion.
Results
Patients with mood disorders and anhedonia at least at one follow-up visit had a 1.4-fold higher risk of suicidal ideation (adjusted odds ratio = 1.35; 95% confidence interval [1.07, 1.70]), even after adjustment for confounding factors of suicide risk (i.e., bipolar or unipolar disorder, sex, age, marital status, education level, antidepressant intake, personal history of suicide attempt, at least one childhood trauma, and mean of the maximum depression score during the follow-up). Conversely, association between anhedonia and suicide attempt did not remain significant after adjustment.
Conclusions
The significant association between anhedonia and suicide ideation in patients with mood disorders stresses the need of targeting hedonia in mood disorders, and of research focusing on the position to pleasure in life through eudaimonia.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Supporting Information
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REFERENCES
- American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders (DSM-5®) ( 5th ed.). Washington, DC.
10.1176/appi.books.9780890425596 Google Scholar
- Amrhein, V., Greenland, S., & McShane, B. (2019). Scientists rise up against statistical significance. Nature, 567(7748), 305–307.
- Arias-Carrión, Ó., & Pöppel, E. (2007). Dopamine, learning, and reward-seeking behavior. Acta Neurobiologiae Experimentalis, 67, 481–488.
- Arsenault, J. T., Rima, S., Stemmann, H., & Vanduffel, W. (2014). Role of the primate ventral tegmental area in reinforcement and motivation. Current Biology, 24, 1347–1353.
- Auerbach, R. P., Millner, A. J., Stewart, J. G., & Esposito, E. C. (2015). Identifying differences between depressed adolescent suicide ideators and attempters. Journal of Affective Disorders, 186, 127–133.
- Ballard, E. D., Vande Voort, J. L., Luckenbaugh, D. A., Machado-Vieira, R., Tohen, M., & Zarate, C. A. (2016). Acute risk factors for suicide attempts and death: Prospective findings from the STEP-BD study. Bipolar Disorders, 18(4), 363–372.
- Ballard, E. D., Wills, K., Lally, N., Richards, E. M., Luckenbaugh, D. A., Walls, T., … Zarate, C. A., Jr. (2017). Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials. Journal of Affective Disorders, 218, 195–200.
- Benningfield, M. M., Blackford, J. U., Ellsworth, M. E., Samanez-Larkin, G. R., Martin, P. R., Cowan, R. L., & Zald, D. H. (2014). Caudate responses to reward anticipation associated with delay discounting behavior in healthy youth. Developmental Cognitive Neuroscience, 7, 43–52.
- Berridge, K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: Hedonics, learning, or incentive salience? Brain Research Reviews, 28, 308–367.
- Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index (PSQI): A new instrument for psychiatric research and practice. Psychiatry Research, 28(2), 193–213.
- Cannon, C. M., & Palmiter, R. D. (2003). Reward without dopamine. Journal of Neuroscience, 23, 10827–10831.
- Casey, P., Dunn, G., Kelly, B. D., Lehtinen, V., Dalgard, O. S., Dowrick, C., & Ayuso-Mateos, J. L. (2008). The prevalence of suicidal ideation in the general population: Results from the Outcome of Depression International Network (ODIN) study. Social Psychiatry and Psychiatric Epidemiology, 43(4), 299–304.
- Claire, D., Raust, A., Fouques, D., Barbato, A., Etain, B., & Henry, C. (2012). Validation of the French version of the functioning assessment short test (FAST) in patients with bipolar disorder. A study from the french bipolar expert centers network. International Clinical Psychopharmacology, 28, e62–e63.
10.1097/01.yic.0000423355.40365.cb Google Scholar
- Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11, 126.
- Deci, E. L. (1972). Intrinsic motivation, extrinsic reinforcement, and inequity. Journal of Personality and Social Psychology, 22, 119–120.
- Ducasse, D., Van Gordon, W., Courtet, P., & Olié, E. (2019). Self-injury and self-concept. Journal of Affective Disorders, 30(258), 115–116.
- Ducasse, D., Jaussent, I., Arpon-Brand, V., Vienot, M., Laglaoui, C., Beziat, S., … Olie, E. (2018). Acceptance and commitment therapy for the management of suicidal patients: A randomized controlled trial. Psychotherapy and Psychosomatics, 6, 1–12.
- Ducasse, D., Loas, G., Dassa, D., Gramaglia, C., Zeppegno, P., Guillaume, S., … Courtet, P. (2018). Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis. Depression and Anxiety, 35(5), 382–392.
- Fawcett, J., Scheftner, W. A., Fogg, L., Clark, D. C., Young, M. A., Hedeker, D., & Gibbons, R. (1990). Time-related predictors of suicide in major affective disorder. American Journal of Psychiatry, 147(9), 1189–1194.
- Franklin, J. C., Ribeiro, J. D., Fox, K. R., Bentley, K. H., Kleiman, E. M., Huang, X., … Nock, M. K. (2017). Risk factors for suicidal thoughts and behaviors: A meta-analysis of 50 years of research. Psychological Bulletin, 143(2), 187–232.
- Giner, L., Blasco-Fontecilla, H., De La Vega, D., & Courtet, P. (2016). Cognitive, emotional, temperament, and personality trait correlates of suicidal behavior. Current Psychiatry Reports, 18(11), 102.
- Gyatso, G. K. (2014). How to understand the mind: The nature and power of the mind. Ulverston, UK: Tharpa Publications.
- Hawes, M., Galynker, I., Barzilay, S., & Yaseen, Z. S. (2018). Anhedonia and suicidal thoughts and behaviors in psychiatric outpatients: The role of acuity. Depression and Anxiety, 35(12), 1218–1227.
- Hawton, K., & van Heeringen, K. (2009). Suicide. Lancet, 373(9672), 1372–1381.
- Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and commitment therapy: Model, processes and outcomes. Behaviour Research and Therapy, 44(1), 1–25.
- Hayes, S. C., Wilson, K. G., Gifford, E. V., Follette, V. M., & Strosahl, K. (1996). Experimental avoidance and behavioral disorders: A functional dimensional approach to diagnosis and treatment. Journal of Consulting and Clinical Psychology, 64(6), 1152–1168.
- Heisel, M. J., & Flett, G. L. (2004). Purpose in life, satisfaction with life, and suicide ideation in a clinical sample. Journal of Psychopathology and Behavioral Assessment, 26, 127–135.
- Henry, C., Etain, B., Mathieu, F., Raust, A., Vibert, J. F., Scott, L., & Leboyer, M. (2011). A french network of bipolar expert centres: A model to close the gap between evidence-based medicine and routine practice. Journal of Affective Disorders, 131(1-3), 358–363.
- Henry, C., M'Bailara, K., Mathieu, F., Poinsot, R., & Falissard, B. (2008). Construction and validation of a dimensional scale exploring mood disorders: MAThyS (Multidimensional Assessment of Thymic States). BMC Psychiatry, 8(1), 82.
- Hoertel, N., Franco, S., Wall, M. M., Oquendo, M. A., Kerridge, B. T., Limosin, F., & Blanco, C. (2015). Mental disorders and risk of suicide attempt: A national prospective study. Molecular Psychiatry, 20(6), 718–726.
- Hosmer, D., & Lemeshow, S. (2000). Applied logistic regression ( 2nd ed.). New York: Wiley Interscience.
10.1002/0471722146 Google Scholar
- Husain, M., & Roiser, J. P. (2018). Neuroscience of apathy and anhedonia: A transdiagnostic approach. Nature Reviews Neuroscience, 19(8), 470–484.
- Jollant, F., Bellivier, F., Leboyer, M., Astruc, B., Torres, S., Verdier, R., … Courtet, P. (2005). Impaired decision making in suicide attempters. American Journal of Psychiatry, 162(2), 304–310.
- Kaczmarek, H. J., & Kiefer, S. W. (2000). Microinjections of dopaminergic agents in the nucleus accumbens affect ethanol consumption but not palatability. Pharmacology, Biochemistry and Behavior, 66, 307–312.
- Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000). FMRI visualization of brain activity during a monetary incentive delay task. NeuroImage, 12, 20–27.
- Lally, N., Nugent, A. C., Luckenbaugh, D. A., Niciu, M. J., Roiser, J. P., & Zarate, C. A., Jr. (2015). Neural correlates of change in major depressive disorder anhedonia following open-label ketamine. Journal of Psychopharmacology, 29(5), 596–607.
- Latimer, L. G., Duffy, P., & Kalivas, P. W. (1987). Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area. Journal of Pharmacology and Experimental Therapeutics, 241(1), 328–337.
- Leyton, M., Boileau, I., Benkelfat, C., Diksic, M., Baker, G., & Dagher, A. (2002). Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: A PET/[11C]raclopride study in healthy men. Neuropsychopharmacology, 27, 1027–1035.
- Liggins, J., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012). The dopamine augmenter L-dopa does not affect positive mood in healthy human volunteers. PLOS One, 7, e28370.
- Loas, G., Azi, A., Noisette, C., Legrand, A., & Yon, V. (2009). Fourteenyear prospective follow-up study of positive and negative symptoms in chronic schizophrenic patients dying from suicide compared to other causes of death. Psychopathology, 42(3), 185–189.
- Loas, G., & Boyer, P. (1993). Relationships between anhedonia and depressive symptoms in major depressive disorder. European Psychiatry, 8, 51–52.
10.1017/S0924933800001553 Google Scholar
- Loas, G., Dubal, S., Perot, P., Tirel, F., Nowaczkowski, P., & Pierson, A. (1997). Validation of the French version of the Snaith-Hamilton Pleasure Scale (SHAPS, Snaith Et Al. 1995). Determination of the statistical parameters in 208 normal subjects and 103 hospitalized patients presenting with depression or schizophrenia. Encephale, 23(6), 454–458.
- Loas, G., Perot, J. M., Chignague, J. F., Trespalacios, H., & Delahousse, J. (2000). Parasuicide, anhedonia, and depression. Comprehensive Psychiatry, 41(5), 369–372.
- Machell, K. A., Goodman, F. R., & Kashdan, T. B. (2015). Experiential avoidance and well-being: A daily diary analysis. Cognition and Emotion, 29(2), 351–359.
- Mallik, A., Chanda, M. L., & Levitin, D. J. (2017). Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone. Scientific Reports, 7, 41952.
- Montgomery, S. A., & Asberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.
- Nock, M. K., Borges, G., Bromet, E. J., Alonso, J., Angermeyer, M., Beautrais, A., … Williams, D. (2008). Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. British Journal of Psychiatry, 192(2), 98–105.
- Paquette, D., Laporte, L., Bigras, M., & Zoccolillo, M. (2004). Validation de la version française du CTQ et prévalence de l'histoire de maltraitance. Santé mentale au Québec, 29(1), 201–220.
- Peciña, S., & Berridge, K. C. (2013). Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered “wanting” for reward: Entire core and medial shell mapped as substrates for PIT enhancement. European Journal of Neuroscience, 37, 1529–1540.
- Peciña, S., Berridge, K. C., & Parker, L. A. (1997). Pimozide does not shift palatability: Separation of anhedonia from sensorimotor suppression by taste reactivity. Pharmacology, Biochemistry and Behavior, 58, 801–811.
- Piray, P., den Ouden, H. E. M., van der Schaaf, M. E., Toni, I., & Cools, R. (2015). Dopaminergic modulation of the functional ventrodorsal architecture of the human striatum. Cerebral Cortex, 27, 485–495.
- Pitchot, W., Hansenne, M., & Ansseau, M. (2001). Role of dopamine in non-depressed patients with a history of suicide attempts. European Psychiatry, 16(7), 424–427.
- Roush, J. F., Brown, S. L., Mitchell, S. M., & Cukrowicz, K. C. (2017). Experiential avoidance, cognitive fusion, and suicide ideation among psychiatric inpatients: The role of thwarted interpersonal needs. Psychotherapy Research, 2, 1–10.
- Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., … Keller, M. B. (2003). The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): A psychometric evaluation in patients with chronic major depression. Biological Psychiatry, 54, 573–583.
- Ryff, C. D. (2014). Psychological well-being revisited: Advances in the science and practice of eudaimonia. Psychotherapy and Psychosomatics, 83(1), 10–28.
- Smith, K. S., & Berridge, K. C. (2007). Opioid limbic circuit for reward: Interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. Journal of Neuroscience, 27, 1594–1605.
- Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995). A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale. British Journal of Psychiattry, 167(1), 99–103.
- Szczypiński, J. J., & Gola, M. (2018). Dopamine dysregulation hypothesis: The common basis for motivational anhedonia in major depressive disorder and schizophrenia? Reviews in the Neurosciences, 29(7), 727–744.
- Thase, M. E., & Rush, A. J. (1997). When at first you don't succeed: Sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry, 58(13), 23–29.
- Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., … Zald, D. H. (2012). Dopaminergic mechanisms of individual differences in human effort-based decision-making. Journal of Neuroscience, 32(18), 6170–6176.
- Treadway, M. T., & Zald, D. H. (2011). Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neuroscience and Biobehavioral Reviews, 35(3), 537–555.
- Van Gordon, W., Shonin, E., Diouri, S., Garcia-Campayo, J., Kotera, Y., & Griffiths, M. D. (2018). Ontological addiction theory: Attachment to me, mine, and I. Journal of Behavioral Addictions, 7, 1–5.
- Van Orden, K. A., Witte, T. K., Cukrowicz, K. C., Braithwaite, S. R., Selby, E. A., & Joiner, T. E., Jr. (2010). The interpersonal theory of suicide. Psychological Review, 117(2), 575–600.
- Wardle, M. C., Treadway, M. T., Mayo, L. M., Zald, D. H., & de Wit, H. (2011). Amping up effort: Effects of D-amphetamine on human effort-based decision-making. Journal of Neuroscience, 31, 16597–16602.
- Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., … Sanacora, G. (2018). The effect of a single dose of intravenous ketamine on suicidal ideation: A systematic review and individual participant data meta-analysis. American Journal of Psychiatry, 175(2), 150–158.
- Winer, E. S., Drapeau, C. W., Veilleux, J. C., & Nadorff, M. R. (2016). The association between anhedonia, suicidal ideation, and suicide attempts in a large student sample. Archives of Suicide Research, 20(2), 265–272.
- Winer, E. S., Nadorff, M. R., Ellis, T. E., Allen, J. G., Herrera, S., & Salem, T. (2014). Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample. Psychiatry Research, 218(1-2), 124–128.
- Xiao, Q., Yue, C., He, W., & Yu, J. Y. (2017). The mindful self: A mindfulness-enlightened self-view. Frontiers in Psychology, 13(8), 1752.
- Yang, X., Wang, D., Liu, S., Liu, G., & Harrison, P. (2019). Stress and suicidal ideation: The role of state or trait anhedonia in a moderated mediation model. Suicide and Life-Threatening Behavior, 50(2), 502–514.
- Yovell, Y., Bar, G., Mashiah, M., Baruch, Y., Briskman, I., Asherov, J., … Panksepp, J. (2016). Ultra-low-dose buprenorphine as a time-limited treatment for severe suicidal ideation: A randomized controlled trial. American Journal of Psychiatry, 173(5), 491–498.
