Neuromuscular Adaptation
V. R. Edgerton
Department of Physiological Science, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorS. Bodine-Fowler
Division of Orthopaedics, VA Medical Center, San Diego, California
Search for more papers by this authorR. R. Roy
Brain Research Institute, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorA. Ishihara
Laboratory of Neurochemistry Faculty of Integrated Human Studies, Kyoto University, Kyoto, Japan
Search for more papers by this authorJ. A. Hodgson
Brain Research Institute, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorV. R. Edgerton
Department of Physiological Science, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorS. Bodine-Fowler
Division of Orthopaedics, VA Medical Center, San Diego, California
Search for more papers by this authorR. R. Roy
Brain Research Institute, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorA. Ishihara
Laboratory of Neurochemistry Faculty of Integrated Human Studies, Kyoto University, Kyoto, Japan
Search for more papers by this authorJ. A. Hodgson
Brain Research Institute, University of California, Los Angeles, Los Angeles, California
Search for more papers by this authorAbstract
The sections in this article are:
- 1 Matching of Motoneurons and Muscle Fiber Properties During Normal Development
- 1.1 Muscle Development
- 1.1.1 Emergence of Fiber Type Diversity
- 1.1.2 Predetermination of Protein Expression
- 1.1.3 Importance of Innervation
- 1.1.4 Specificity of Neuronal Connections to Muscle
- 1.1.5 Projection Patterns
- 1.1.6 Positional Guidance Cues
- 1.1.7 Contact-Mediated Cues
- 1.1.8 Chemotrophic Cues
- 1.1.9 Formation of Neuromuscular Junctions
- 1.2 Motoneuron Development
- 1.2.1 Regulation of Neuronal Population Size
- 1.2.2 Target Size and Trophic Factors
- 1.2.3 Motoneuron Physiology
- 1.2.4 Heterogeneity of Motoneuron Properties
- 1.3 Synapse Elimination
- 1.3.1 Competition vs. Intrinsic Withdrawal
- 1.3.2 Activity and Synapse Elimination
- 1.3.3 Role of Competition between Axons
- 1.3.4 Innervation of Muscle Fiber Types and the Role of Synapse Elimination
- 1.3.5 Positional Cues and Synapse Elimination
- 1.4 Summary
- 1.1 Muscle Development
- 2 Neural and Nonneural Sources of Control of Adult Skeletal Muscle Properties
- 2.1 Cross-Reinnervation
- 2.1.1 Physiological Properties
- 2.1.2 Biochemical Properties
- 2.1.3 Histochemical and Immunohistochemical Properties
- 2.1.4 Motor Unit Properties
- 2.1.5 Limitations
- 2.2 Prolonged Electrical Silence
- 2.2.1 Surgically Induced Inactivity
- 2.2.2 Pharmacologically Induced Inactivity
- 2.1 Cross-Reinnervation
- 3 Morphological and Metabolic Properties of Motoneurons
- 3.1 Relationship of Soma Size and Metabolic Properties
- 3.2 Adaptability of Soma Size and Metabolic Properties
- 4 Gene Amplification Within a Motor Unit
- 5 Overall Summary
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