Divergent Synthesis of Four Types of Fused N-Containing Heterocycles via Oxidative Multi-Component Cyclization Reaction
Xiaoshuang Guo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018 China
Search for more papers by this authorMaozhong Miao
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018 China
Search for more papers by this authorCorresponding Author
Peng Zhao
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yongmin Ma
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorXiaoshuang Guo
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018 China
Search for more papers by this authorMaozhong Miao
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018 China
Search for more papers by this authorCorresponding Author
Peng Zhao
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yongmin Ma
Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
An atmospheric-oxygen-mediated four-component reaction was developed for the divergent synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine derivatives from readily available alcohols and 3-aminopyrazoles. In this transformation, atmospheric oxygen serves as the green oxidant, promoting alcohols as equivalent aldehydes for the synthesis of four types of N-containing heterocycles (> 40 examples). Remarkably, the transformation features metal-free and molecular diversity.
Supporting Information
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