Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods
Xuliang Han
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorHaodong Liu
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorXiaomei Feng
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorFuchao Jia
School of Physics and Optoelelctronic Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorZengdian Zhao
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorCorresponding Author
Xinjin Li
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
E-mail: [email protected]Search for more papers by this authorXuliang Han
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorHaodong Liu
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorXiaomei Feng
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorFuchao Jia
School of Physics and Optoelelctronic Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorZengdian Zhao
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
Search for more papers by this authorCorresponding Author
Xinjin Li
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.
Supporting Information
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