Volume 41, Issue 2 p. 134
Inside Cover Picture
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Inside Cover Picture

First published: 15 December 2022

Abstract

This cover picture describes a novel palladium-catalyzed three-component tandem cyclization reaction between two molecular haloalkynes and one molecular N-alkylaniline for the efficient assembly of 3-halopyrroles. This protocol involves the sequential conversions of two carbon-carbon triple bonds and one carbon-halogen bond in two molecular haloalkynes and features convenient operation, high chemo- and regioselectivites, and good functional group tolerance. In addition, different derivatizations of the newly formed bromopyrroles afford diverse functionalized pyrrole derivatives, demonstrating the practicability of this method. More details are discussed in the article by Wu et al. on page 181—187.

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