Anti-proliferative Properties of Schinensilactone A, A Schinortriterpenoid with 7,8-Seco-1,8-cyclo Scaffold against Caco-2 by Inducing Cell Apoptosis from the Leaves of Schisandra chinensis
Correction(s) for this article
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Corrigendum
- Volume 41Issue 4Chinese Journal of Chemistry
- pages: 490-490
- First Published online: January 15, 2023
Yan Liu
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorGuo-Zhen Liu
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorXiao-Mao Li
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorPeng Jiang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorYong-Gang Xia
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
E-mail: [email protected]; [email protected]Search for more papers by this authorYan Liu
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorGuo-Zhen Liu
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorXiao-Mao Li
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorPeng Jiang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorYong-Gang Xia
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, 150040 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
A novel schinortriterpenoid (SNT), schinensilactone A (1), characterized by a unique 7,8-seco-1,8-cyclo-schisanartane scaffold, was isolated from the leaves of Schisandra chinensis (Turcz.) Baill, together with a new SNT (schinensilactone B, 2) and two known (3, 4). Their structures were elucidated using spectroscopy and X-ray diffraction. Furthermore, a hypothetical biosynthetic pathway for 1 was postulated due to its novel carbon skeleton. In addition, 1 exhibited significant anti-proliferative activity against Caco-2 cells originating from five different tumor cell lines, and its preliminary mechanism of action was investigated with respect to the expression of apoptosis-related proteins, including P53, Caspase 3, Bax, PUMA, and Bcl2. These biological activities would further our understanding of the food function of Schisandra chinensis leaves.
Supporting Information
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Appendix S1: Supporting Information |
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