Cornerstones in Chemistry
Catellani Reaction: An Enabling Technology for Vicinal Functionalization of Aryl Halides by Palladium(0)/Norbornene Cooperative Catalysis
Sichan Dong,
Xinjun Luan,
Sichan Dong
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710127 China
Search for more papers by this authorCorresponding Author
Xinjun Luan
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710127 China
E-mail: [email protected]Search for more papers by this authorSichan Dong,
Xinjun Luan,
Sichan Dong
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710127 China
Search for more papers by this authorCorresponding Author
Xinjun Luan
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710127 China
E-mail: [email protected]Search for more papers by this authorAbstract
The Catellani reaction, originally discovered by Catellani in 1997, and further developed by Catellani, Lautens and others, has emerged as a powerful strategy for the synthesis of polysubstituted arenes, which would be difficult to access via traditional methods. In this process, both ortho- and ipso-positions of aryl halides could be functionalized simultaneously with different electrophiles and terminating agents under the cooperative catalysis of palladium and norbornene (NBE). This review focuses on the significant progress of such transformations, and the section of typical Catellani reactions is divided into five parts according to the functionalization mode of ortho-C—H bond: alkylation, arylation, amination, acylation or thiolation.
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