Volume 36, Issue 4 p. 372
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Back Cover: Internally Reuse Waste: Catalytic Asymmetric One-Pot Strecker Reaction of Fluoroalkyl Ketones, Anilines and TMSCN by Sequential Catalysis (Chin. J. Chem. 4/2018)

Yun-Lin Liu

Corresponding Author

Yun-Lin Liu

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 China

Current address: School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, Guangdong 510006, ChinaE-mail: [email protected]; [email protected]Search for more papers by this author
Xiao-Ping Yin

Xiao-Ping Yin

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 China

Search for more papers by this author
Jian Zhou

Corresponding Author

Jian Zhou

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 China

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062 China

E-mail: [email protected]; [email protected]Search for more papers by this author
First published: 14 March 2018

Abstract

A highly enantioselective one-pot Strecker reaction of α-fluoroalkyl α-aryl ketones, anilines, and TMSCN is disclosed, which simultane-ously reuses water byproduct and catalyst from the ketimine formation step as a promoter and an additive to improve the reactivity and enantioselectivity of the subsequent Strecker reaction, respectively. The picture shows that the chiral bifunctional tertiary amine mediated asymmetric Strecker reaction is irrigated by the water generated in the p-TsOH catalyzed ketimine formation, and fertilized by the remaining acid catalyst. More details are discussed in the article by Zhou et al. on page 321–328.

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