Cover Picture: Supramolecular Prodrug Micelles Constructed by Drug-Drug Conjugate with Water Soluble Pillar[6]arene for Controllable and Rapid Drug Release (Chin. J. Chem. 3/2015)
Graphical Abstract
The cover picture shows the construction of novel supramolecular prodrug micelles based on the host-guest interaction of water-soluble pillar[6]arene (WP6) and doxorubicin (DOX)-based drug-drug conjugate (G). Herein, the release rate of DOX from these supramolecular micelles is approximate to 100% within 30 min at pH 5.5 by simulating the endo-lysosomal environment. Significantly, intracellular localization experiments demonstrated that these supramolecular micelles, taken up by cancer cells via endocytosis, can lead to efficient DOX accumulation in SKOV3 cancer cells, implying its promising future for cancer therapy. More details are discussed in the article by Hu et al. on page 329–334.
