β-Cyclodextrin and Its Derivatives Functionalized Magnetic Nanoparticles for Targeting Delivery of Curcumin and Cell Imaging
Yehong Zhou
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorCongli Wang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorFei Wang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorChenzhong Li
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Department of Biomedical Engineering, Florida International University, Miami, Florida, USA
Search for more papers by this authorChuan Dong
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorCorresponding Author
Shaomin Shuang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China, Tel.: 0086-0351-7018842; Fax: 0086-0351-7011688Search for more papers by this authorYehong Zhou
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorCongli Wang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorFei Wang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorChenzhong Li
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Department of Biomedical Engineering, Florida International University, Miami, Florida, USA
Search for more papers by this authorChuan Dong
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Search for more papers by this authorCorresponding Author
Shaomin Shuang
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China
Department of Chemistry and Chemical Engineering and Institute of Environmental Science, Shanxi University, Taiyuan, Shanxi 030006, China, Tel.: 0086-0351-7018842; Fax: 0086-0351-7011688Search for more papers by this authorAbstract
β-Cyclodextrin (β-CD) and its derivatives functionalized magnetic nanoparticles (MNPs) with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxypropyl/sulfobutyl ether-β-CD-MNPs (CM/HP/SBE-β-CD-MNPs) nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as-prepared nanocarriers for the hydrophobic anti-cancer drug curcumin was also investigated. The results revealed that the SBE-β-CD-MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE-β-CD-MNPs entered into the cell, and curcumin could be successfully delivered into the cell by SBE-β-CD-MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE-β-CD-MNPs were non-toxic, while curcumin loaded SBE-β-CD-MNPs showed high potential to kill the HepG2 cells. The as-prepared magnetic composites were expected to expand their potential applications in biomedical field.
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