A Novel and Facile Synthesis of 2-(Benzofuran-2-yl)benzo[h]quinoline-3-carboxylic Acid Derivatives
Corresponding Author
Wentao Gao
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China, Tel.: 0416-3400266; Fax: 0416-3400266Search for more papers by this authorYun Jiang
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorYang Li
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorFeng Li
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorYan Yan
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorCorresponding Author
Wentao Gao
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China, Tel.: 0416-3400266; Fax: 0416-3400266Search for more papers by this authorYun Jiang
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorYang Li
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorFeng Li
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorYan Yan
Institute of Superfine Chemicals, Bohai University, Jinzhou, Liaoning 121000, China
Search for more papers by this authorAbstract
A simple and concise approach for the synthesis of a series of new heterocyclic systems of 2-(benzofuran-2-yl)benzo[h]quinoline-3-carboxylic acid derivatives (3a–3g) is described. The synthetic strategy features the one-pot reaction of ethyl 2-(chloromethyl)benzo[h]quinoline-3-carboxylate (2) with various substituted salicylaldehydes as well as 2-hydroxy-1-naphthaldehyde as a key step. The substrate 2 was prepared in good yield by a mild, efficient and direct reaction of 1-naphthylamine (1) with Vilsmeier-Haack reagent. The structures of all the new compounds were identified by spectral data and elemental analysis.
Supporting Information
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