Influence of Low Cetyltrimethylammonium Bromide Concentration on the Interactions and Properties of Hemoglobin with Acyclovir

Tian-Qing Liu,

Tian-Qing Liu

School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210093, China

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Rong Guo,

Rong Guo

[email protected]

Project supported by the National Natural Science Foundation of China (Nos. 20573091, 20233010).

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Tian-Qing Liu,

Tian-Qing Liu

School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210093, China

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Rong Guo,

Rong Guo

[email protected]

Project supported by the National Natural Science Foundation of China (Nos. 20573091, 20233010).

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First published: 16 May 2006

https://doi.org/10.1002/cjoc.200690119

Citations: 12

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Abstract

The effects of cetyltrimethylammonium bromide (CTAB) on the properties of hemoglobin (Hb) at low CTAB concentration were studied in Hb/acyclovir/CTAB system by the methods of UV-Vis spectrum, fluorescence, zeta potential, conductivity and negative-staining transmission electron microscope (TEM). With the increase of CTAB concentration, the UV peak intensity at 276 nm, the intrinsic fluorescence, the zeta potential of Hb and the system conductivity were all enhanced. Hb was easily oxidized to oxyHb and hemichrome. In Hb/acyclovir/CTAB system, CTAB made the UV-Vis spectrum, fluorescence, conductivity and conformation of Hb tend to be returned to those of the original Hb but the zeta potential not to do so. The UV absorption peak of Hb-acyclovir complex disappeared, and the tight structure of Hb aroused by acyclovir was refolded. When CTAB concentration was higher than 5×10⁻⁵ mol/L, the two absorption peaks at 536 and 576 nm appeared again, and the Hb structure became looser again.

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Volume24, Issue5

May, 2006

Pages 620-626

Influence of Low Cetyltrimethylammonium Bromide Concentration on the Interactions and Properties of Hemoglobin with Acyclovir

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Influence of Low Cetyltrimethylammonium Bromide Concentration on the Interactions and Properties of Hemoglobin with Acyclovir

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