Volume 24, Issue 4 pp. 504-508
Full Paper

Synthesis of Novel Nucleoside Analogues Based on 1,3-Dihydrobenzo[c]furan Core

Zhao-Peng Liu

Zhao-Peng Liu

Project supported by the Scientific Research Foundation for the Returned Oversea Chinese Scholars of Shandong University.

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Zhao-Li Meng

Zhao-Li Meng

Department of Organic Chemistry, School of Pharmaceutical Science, Shandong University, Jinan, Shandong 250012, China

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De-Feng Wang

De-Feng Wang

Department of Organic Chemistry, School of Pharmaceutical Science, Shandong University, Jinan, Shandong 250012, China

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First published: 05 April 2006
Citations: 3

Abstract

A novel efficient synthetic route to 1,3-dihydrobenzo[c]furan glycone was developed and the corresponding 5-fluoro, 5-iodo uracil and guanosine derivatives, the aromatic analogues of the well known antiviral 2′,3′-dideoxy-2′,3′-dihydronucleosides (d4N), were synthesized.

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