Influence of Emulsifiers on the Synthesis of Insulin-loaded Nanocapsules in Double Emulsion
Project supported by the Key Project of the National Natural Science Foundation of China (No. 20233010).
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Abstract
Insulin entrapped nanocapsules to use polylactide (PLA) as the encapsulating material were prepared through a modified water-in-oil-in-water (W/O/W) emulsification and solvent evaporation method. The average particle size of PLA nanocapsules obtained was decreased to (181.5±8.4) nm, and capably adjusted from 180 to 370 nm by using different types and content of nonionic emulsifiers. The influence of emulsifiers on property of nanocapsules was discussed in detail. The effects of spans and tweens to modify the size of the nanocapsules were different, which can be due to the distribution of the surfactants on the inner interface between the inner water and oil of the double emulsion. The encapsulation efficiency and drug release of nanocapsules were affected obviously by the content and type of emulsifiers.
