12α,13-Dihydroxyolean-3-oxo-28-oic acid, a New Triterpene, and the Known Oleanonic Acid as a New Cell Cycle Inhibitor from Schefflera venulosa
Project supported by the National Natural Science Foundation for Distinguished Young Scholars of China (No. 39825126), the Major State Basic Research Development Program (No. 1998051113), and the Cheung Kong Scholar from the Cheung Kong Scholars Program of Ministry of Education of China.
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Abstract
12±,13-Dihydroxyolean-3-oxo-28-oic acid (1), a new pentacyclic triterpene, was isolated from Schefflera venulosa (Wight et Arn.) Harms through a bioassay-guided fractionation procedure, together with the known oleanonic acid (2) as a new cell cycle inhibitor. Structures were established by spectroscopy. Compound 2 inhibited the proliferation of K562 cells with the IC50 value of 0.13 µmol/mL by the SRB method and inhibited the cell cycle of tsFT210 cells at the G0/G1 phase at the concentration higher than 10 µg/mL.
