In dichloromethane, the nucleophilic addition of alcohols or phenols to 3,4-dihydro-2H-pyran (DHP) was catalyzed effectively by gallium triiodide which was generated in situ by the reaction of gallium metal and iodine to give the corresponding tetrahydropyranyl acetals in good to excellent yields.

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Volume22, Issue11

November 2004

Pages 1341-1343

Gal₃ catalyzed tetrahydropyranylation of alcohols and phenols

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Gal3 catalyzed tetrahydropyranylation of alcohols and phenols

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Gal₃ catalyzed tetrahydropyranylation of alcohols and phenols