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Synthesis and Electrospray Ionization Mass Spectra of Amino Acid Thiophosphoramidates of Nucleoside^†

Zhi-Wei Miao

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Hua Fu,

Hua Fu

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Yi Chen,

Yi Chen

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Jingd Chen,

Jingd Chen

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Chang-Mei Cheng,

Chang-Mei Cheng

[email protected]

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Yu-Fen Zhao,

Yu-Fen Zhao

[email protected]

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Zhi-Wei Miao,

Zhi-Wei Miao

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Hua Fu,

Hua Fu

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Yi Chen,

Yi Chen

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Jingd Chen,

Jingd Chen

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Chang-Mei Cheng,

Chang-Mei Cheng

[email protected]

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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Yu-Fen Zhao,

Yu-Fen Zhao

[email protected]

Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

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First published: 26 August 2010

https://doi.org/10.1002/cjoc.20010191213

Citations: 5

^†

Dedicated to Professor HUANG Wei-Yuan on the occasion of his 80th birthday.

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Abstract

Amino acid thiophosphoramidates of nucleoside were synthesized and determined by negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). Hie fragmentation pathways were investigated. The results show that ESI-MS is a useful tool for structural determination of amino acid thiophosphoramidates of nucleoside.

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Volume19, Issue12

December 2001

Pages 1239-1244

Synthesis and Electrospray Ionization Mass Spectra of Amino Acid Thiophosphoramidates of Nucleoside^†

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Synthesis and Electrospray Ionization Mass Spectra of Amino Acid Thiophosphoramidates of Nucleoside†

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Synthesis and Electrospray Ionization Mass Spectra of Amino Acid Thiophosphoramidates of Nucleoside^†