Article
Full Access
Synthesis, structure and antitumor activity of dibutyltin oxide complex with 5-fluorouracil derivatives
Abstract
The dibutyltin(IV) oxide complex reacts with 5-fluorouracil-l-propanonic or5-fluorouracil-1-acetic acid to give the potential antitumor activity complexes [(5-fluorouracil)-1-(CH2)mCOOSn(Bu-n)2]4O2[m = 1, (1); m = 2, (2)] which were determined by IR and 1H NMR. The crystal structure determination shows that complex 2 is a dimmer, in which two [(5-fluorouracil)-1-CH2CH2COOSn(Bu-n)2]2O units are linked by bridging oxygen atom, and the tin atoms adopt distorted trigonal bipyramids via two carbons from dibutyl group and three oxygen atoms from 5-fluorouracil and bridging oxygen. In vitro test shows complexes 1 and 2 exhibit high cytotoxicity against OVCAR-3 and PC-14.
