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Asymmetric reduction of aminoketones with borane and chiral oxazaborolidine catalyst
Abstract
A group of α- and β-N, N-dialkyl amino ketones were reduced enantioselectively by 2 moles of borane-tetrahydrofuran in the presence of 10 mol% of the in-situ formed chiral oxazaborolidine, followed by diluted hydrochloric acid. The resulting amino alcohol-borane complexes were treated with hydrogen chloride-glycol-methanol to give the optically active amino alcohol with the ee up to 99%.
