Synthesis of Novel Chiral Biphenylamine Ligand 6,6'-Dimethoxy-2,2′-diaminobiphenyl
Yi-Xin Chen
Department of Chemistry, Guangzhou University, Guangzhou, Guangdong 510405, China
Search for more papers by this authorYue-Ming Li
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorKim-Hung Lam
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorAltera S. C. Chan
Department of Chemistry, Guangzhou University, Guangzhou, Guangdong 510405, China
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorYi-Xin Chen
Department of Chemistry, Guangzhou University, Guangzhou, Guangdong 510405, China
Search for more papers by this authorYue-Ming Li
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorKim-Hung Lam
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorAltera S. C. Chan
Department of Chemistry, Guangzhou University, Guangzhou, Guangdong 510405, China
Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Search for more papers by this authorAbstract
A new chiral ligand 6,6′-dimethoxy-2,2′-diaminobiphenyl was successfully prepared from 3-nitrophenol via iodination, Ullmann coupling, and reduction. The resolving reagent (2R, 3R)- or (2S,3S)-2,3-di (phenylaminocarbonyl)tartaric acid was prepared from commercially available tartaric acid in large scale and was used to resolve the racemic 6,6′-dimethoxy-2,2′-diaminobiphenyl. The chiral 6,6′- dimethoxy-2,2′-diaminobiphenyl obtained was proved to be enantiomerically pure.
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