A series of pyridone derivatives were synthesized by the reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and ammonium acetate under microwave irradiation in the absence of solvent. The reactions were completed within 3-5 min to give the desired products in 72.4-86.2% yields.

References

1(a) Janis, R. A.; Silver, P. J.; Triggle, D. J., Adv. Drug Res. 1987, 16, 309.
CAS Google Scholar
(b) Bossert, F; Vater, W., Med. Res. Rev. 1989, 9, 291.
10.1002/med.2610090304
CAS PubMed Web of Science® Google Scholar
2(a) Eisner, U; Kuthan, J., Chem. Rev. 1972, 72, 1.
10.1021/cr60275a001
CAS Web of Science® Google Scholar
(b) Stout, D. M.; Meyers, A. I., Chem. Rev. 1982, 82, 223.
10.1021/cr00048a004
CAS Web of Science® Google Scholar
3(a) Chorvat, R. J.; Rorig, K. J., J. Org. Chem. 1988, 53, 5779.
10.1021/jo00259a033
CAS Web of Science® Google Scholar
(b) Kappe, C. O.; Fabian, W. M. F., Tetrahedron 1997, 53, 2803.
10.1016/S0040-4020(97)00022-7
CAS Web of Science® Google Scholar
(c) Kappe, C. O., Tetrahedron 1993, 49, 6937.
10.1016/S0040-4020(01)87971-0
CAS Web of Science® Google Scholar
4 Svêtlfk, J; Goljer, I; Turecek, F., J. Chem. Soc., Perkin Trans. 1, 1990, 1315.
Google Scholar
5 Morales, A; Ochoa, E; Suarez, M; Verdecia, Y; Gonzalez, L; Martin, N; Quinteiro, M; Seoane, C; Soto, J. L., J. Heterocycl. Chem. 1996, 33, 103.
10.1002/jhet.5570330118
CAS Web of Science® Google Scholar
6 Surez, M.; Ochoa, E.; Verdecia, Y.; Pita, B.; Morán, L.; Mortín, N.; Quinteiro, M.; Seoane, C.; Soto, J. L.; Novoa, H.; Blaton, N.; Peters, O. M., Tetrahedron 1999, 55, 875.
10.1016/S0040-4020(98)01078-3
CAS Web of Science® Google Scholar
7 X-ray crystallography for 5a: Empirical formula C₁₅H₁₇NO₃, F. W. 259.30, T = 293(2) K, Triclinic, space group PI, a = 0.78700(16) nm, b = 0.92900(19) nm, c = 1.0640 (2) nm, α= 102.79(3)°, β= 110.42(3)°, γ=96.92(3)°, V= 0.6942(2) nm³, Z = 2, D_c = 1.240 Mg/m³, λ(Mo K_a) = 0.071073 nm, μ = 0.086 mm⁻¹, F(000)=276, 2.13° < θ < 24.98°, R=0.0423, R_w = 0.1257, S= 1.014, largest diff. peak and hole; 214 and −152 e.nm⁻³.
Google Scholar
8 X-ray crystallography for 7b: Empirical formula C₁₇H₁₈ClNO₂, F. W. 303.77, T = 293(2) K, monoclinic, space group C2/c, a = 2.3677(5) nm, b=0.95333(19) nm, c = 1.4027(3) nm, α = 90°, β = 98.03(3)°, γ = 90°, V = 3.1349 (11) nm³, Z = 8, D_c= 1.287 Mg/m³, λ(Mo K_a)= 0.071073 nm, μ = 0.247 mm⁻¹, F(000) = 1280, 3.48° < θ < 27.99°. R = 0.0600. R_w = 0.1959. S = 0.839, largest diff. peak and hole: 384 and −496 e.nm⁻³.
Google Scholar

Citing Literature

Volume19, Issue7

July 2001

Pages 714-715

Microwave Assisted Synthesis of Pyridone Derivatives

Abstract

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Microwave Assisted Synthesis of Pyridone Derivatives

Abstract

References

Citing Literature

References

Related

Information