Synthesis and Hill Inhibitory Activity of New Substituted 3-Aryl-5-cyano-6-methylthio Pyrimidine-2, 4-diones

Novel substituted derivatives of 3-aryl-5-cyano-6-methylthiopyrimidine-2, 4-diones were synthesized by the reaction of ethyl 2-cyano-3,3′-dimethylthioacrylate with arylureas in good yields. The structures of all title compounds were evaluated by elemental analyses and ¹H NMR spectra and compound 2c was also confirmed by X-ray diffraction. Hill reaction inhibitory activity of title compounds was assayed.