Iotroridoside-A, a Novel Cytotoxic Glycosphingolipid from the Marine Sponge Iotrochota ridley

A new cytotoxic glycosphingolipid, Iotroridoside-A, was isolated from the marine sponge Iotrochota ridley collected from the South China Sea near Hainan Island, China. On the basis of chemical degradation method and IR, MS, ¹H NMR, ¹³C NMR and 2D NMR spectrometry, its structure was assigned as 1-O-β-D-glucopyranosyl-2-[(4′ Z)-2′-hydroxytetracosene amido]-4-tetradecyl-1, 3, 4-butantriol. The new compound exhibits strong cytotoxicity against L1210 murine leukemia cells in vitro (ED₅₀ = 0.08 μg/mL).