Direct synthesis of 3-fluoroalkyl-2,6-diethoxycarbonyl phenols
Guan Hui-Ping
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorHu Qiao-Sheng
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorHu Chang-Ming
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorGuan Hui-Ping
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorHu Qiao-Sheng
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorHu Chang-Ming
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorAbstract
Cyclocondensation of α-fluoroalkyl ketones or α-fluoroalkyl aldehyde (1) and diethyl 1,3-acetonedicarboxylate (2) affords 3-fluoroalkyl-2,6-diethoxycarbonyl-5-alkyl-phenols (3) in good yields. This provides a novel method for the preparation of meta-fluoroalkyl polysubstituted phenols.
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