ChemInform Abstract: Versatile Approaches for the Synthesis of Fused-Ring γ-Lactones Utilizing Cyclopropane Intermediates.
Abstract
Five sequences demonstrate the usefulness for the construction of a range of bi- and tricyclic functionalized lactones with control of stereochemistry and a minimum of synthetic steps, involving an acid-catalyzed cyclopropylester to γ-lactone skeletal rearrangement.