Volume 42, Issue 21
Heterocyclic Compounds

ChemInform Abstract: Two-Step Synthesis of 1,3-Disubstituted 3,4-dihydro-4-thioxoquinazolin-2(1H)-ones from 1-Bromo-2-fluorobenzenes.

Kazuhiro Kobayashi

Kazuhiro Kobayashi

Dep. Chem. Biotechnol., Grad. Sch. Eng., Tottori Univ., Koyama, Tottori 680, Japan

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Toshihide Komatsu

Toshihide Komatsu

Dep. Chem. Biotechnol., Grad. Sch. Eng., Tottori Univ., Koyama, Tottori 680, Japan

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Yuki Yokoi

Yuki Yokoi

Dep. Chem. Biotechnol., Grad. Sch. Eng., Tottori Univ., Koyama, Tottori 680, Japan

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Hisatoshi Konishi

Hisatoshi Konishi

Dep. Chem. Biotechnol., Grad. Sch. Eng., Tottori Univ., Koyama, Tottori 680, Japan

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First published: 28 April 2011

Abstract

Benzothioamides (III) undergo addition—substitution with phenyl isocyanate (IV) to give the desired thioxoquinazolinones (Va)-(Vc) in good yields.

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