Other Subjects
ChemInform Abstract: Design and Synthesis of 1,4-Dihydropyridine Derivatives as BACE-1 Inhibitors.
Abstract
Using structure-based drug design based on computer-aided molecular docking, an isophthalamide moiety in a known BACE-1 inhibitor is replaced by the 1,4-dihydropyridine (DHP) skeleton with assumed enhanced permeability through the blood-brain barrier.
