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ChemInform Abstract: Synthesis and Mannosidase Inhibitory Activity of 3-Benzyloxymethyl Analogues of Swainsonine.
First published: 22 May 2010
Abstract
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ChemInform Abstract
In order to avoid potential problems arising from co-inhibition of lysosomal mannosidases, 3-benzyloxymethyl analogues such as (V) of swainsonine, a potent inhibitor of Golgi α-mannosidase II are prepared and screened against jack bean α-mannosidase. Preliminary results reveal that some of the products (no details given) exceed the activity of swainsonine.
