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ChemInform Abstract: Chiral Base Route to Cyclic Polyols: Asymmetric Synthesis of Aminodeoxyconduritols and Conduritol F.
First published: 22 May 2010
Abstract
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ChemInform Abstract
Ring-opening of the meso-epoxide (II) in the presence of a chiral base provides the chiral allylic alcohol (III) as key intermediate for aminodeoxyconduritols (V) and (VII). To demonstrate the utility of the enantioselective epoxide-opening conduritol F tetraacetate (X) is prepared from the isomeric allylic alcohol (VIII).
