Volume 32, Issue 49
Natural Products
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ChemInform Abstract: Stereospecific Synthesis of trans-Arachidonic Acids.

U. Murali Krishna

U. Murali Krishna

Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA

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M. Muralidhar Reddy

M. Muralidhar Reddy

Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA

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Jianing Xia

Jianing Xia

Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA

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J. R. Falck

J. R. Falck

Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA

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Michael Balazy

Michael Balazy

Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA

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First published: 23 May 2010

Abstract

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ChemInform Abstract

A synthetic procedure to convert cis-arachidonic acids (I) into corresponding trans-isomers (II) applicable on all four double bonds is described. The prepared trans-compounds can be used to investigate the role of trans-arachidonic acids in cardiovascular diseases.

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