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ChemInform Abstract: Concise Synthesis of Ciguatoxin ABC-Ring Fragments and Surface Plasmon Resonance Study of the Interaction of Their BSA Conjugates with Monoclonal Antibodies.
First published: 24 May 2010
Abstract
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ChemInform Abstract
A new, more concise and convergent route to the ABC-ring fragment of ciguatoxin (XI) and the synthesis of related analogue (XIV) starting from commercially available protected D-glucal (I) are described. Interactions of corresponding hapten—BSA conjugates with monoclonal antibodies are studied by surface plasmon resonance spectroscopy.
