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ChemInform Abstract: Total Synthesis and Stereochemical Revision of (+)-Aeruginosin 298-A.
First published: 27 May 2010
Abstract
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ChemInform Abstract
Synthesis of key intermediate (VII) is based on the recently published oxidative cyclization of L-tyrosine. Preparation of aeruginosin incorporating the proposed L-leucine residue is mentioned to fail in providing the natural product. Thus, the structure of title thrombin inhibitor (VIII) is reassigned to contain a D-leucine moiety.
