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ChemInform Abstract: Efficient Synthesis of Protected 3′-Deoxyadenosine and 3′-Deoxyguanosine from Adenosine and Guanosine.
First published: 27 May 2010
Abstract
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ChemInform Abstract
Regioselective deoxygenation of adenosine and guanosine derivatives (I) is achieved by reaction with α-acetoxyisobutyryl bromide (II) and subsequent tin hydride reduction. The route can be enhanced to preparative scale.
