ChemInform Abstract: Formation of 1,2-Oxazine Derivatives: A Novel Type of Reaction Between 2-Aminooxazoles and Maleic Acid Imide.
Abstract
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ChemInform Abstract
Reaction of N,N-disubstituted 2-aminooxazoles with maleimide (II) results in the formation of alkylidenesuccinimides (III) or pyrrolooxazines (V) depending on the substitution pattern of starting oxazoles. The formation of the fused heterocycles (V) is explained by an unprecedented C5—O bond cleavage of oxazoles (IV) followed by ring closure of the intramolecular diene synthesis type.