ChemInform Abstract: Isoquinoline Derivatives. Synthesis and Antiarrhythmic Properties of 1-Nitrophenyl-6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoqui nolines.
Abstract
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ChemInform Abstract
The antiarrhythmic activity of compounds (III)—(V), (VII), and (VIII) is studied using two different models. Interestingly, the acyclic analogues of title isoquinolines, namely (III), (VII), and (VIII), possess the highest activity.