Volume 32, Issue 18
Heterocyclic Compounds
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ChemInform Abstract: Sulfonylated Aminothiazoles as New Small Molecule Inhibitors of Protein Phosphatases.

Peter Wipf

Peter Wipf

Dep. Chem., Univ. Pittsburgh, Pittsburgh, PA 15260, USA

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Diana C. Aslan

Diana C. Aslan

Dep. Chem., Univ. Pittsburgh, Pittsburgh, PA 15260, USA

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Eileen C. Southwick

Eileen C. Southwick

Dep. Chem., Univ. Pittsburgh, Pittsburgh, PA 15260, USA

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John S. Lazo

John S. Lazo

Dep. Chem., Univ. Pittsburgh, Pittsburgh, PA 15260, USA

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First published: 27 May 2010

Abstract

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ChemInform Abstract

A series of N-sulfonated aminothiazoles (V) (ca. 40 examples) are synthesized and evaluated for their ability to inhibit protein phosphatases in vitro.

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